Peptide nucleic acid-metal complex conjugates: Facile modulation of PNA-DNA duplex stability

被引：37

作者：

Mokhir, A ^{[1
]}

Stiebing, R ^{[1
]}

Kraemer, R ^{[1
]}

机构：

[1] Heidelberg Univ, Inst Anorgan Chem, D-69120 Heidelberg, Germany

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 08期

关键词：

D O I：

10.1016/S0960-894X(03)00175-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Conjugates of peptide nucleic acids (PNA) and metal binding ligands were prepared using solid-phase synthesis. Stability of duplexes of bis-picolylamine-PNA conjugates and DNA was found to be modulated by equimolar concentrations of bioavailable metal ions: Ni2+, Zn2+ > Cu2+. Sequence specificity of PNA was not compromised in the presence of these metal ions. (C) 2003 Elsevier Science Ltd. All rights reserved.

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页码：1399 / 1401

页数：3

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