Phosphorylcholine-based polymers and their use in the prevention of biofouling

被引：432

作者：

Lewis, AL ^{[1
]}

机构：

[1] Biocompatibles Ltd, Surrey GU9 8QL, England

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 2000年 / 18卷 / 3-4期

关键词：

phosphorylcholine-containing polymers; biomimetic surfaces; protein adhesion resistance; cell adhesion resistance; medical devices;

D O I：

10.1016/S0927-7765(99)00152-6

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

This article provides an overview of work carried out on the synthesis and non-fouling properties of phosphorylcholine (PC)-containing: polymers. The concept of biomimiery is outlined and the major classes of synthetic PC-based materials described. Studies on the interaction of these materials with various proteins are collated and the mechanism for their protein-resistant nature is discussed. Similarly, cellular interactions are also reviewed, with ex-vivo and in-vivo clinical data provided to demonstrate the usefulness of these materials for improving the properties of medical devices. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：261 / 275

页数：15

共 122 条

[31] BIOMEMBRANES AS MODELS FOR POLYMER SURFACES .5. THROMBOELASTOGRAPHIC STUDIES OF POLYMERIC LIPIDS AND POLYESTERS [J].