Luminescent nanoparticle probes for bioimaging

被引:77
作者
Santra, S
Xu, JS
Wang, KM
Tan, WH [1 ]
机构
[1] Univ Florida, Ctr Res Bio Nano Interface, Dept Chem, Gainesville, FL 32611 USA
[2] Univ Florida, McKnight Brain Inst, Gainesville, FL 32611 USA
[3] Univ Florida, Dept Neurol Surg, Gainesville, FL 32610 USA
[4] Hengyang Normal Univ, Hengyang 421008, Peoples R China
[5] Hunan Univ, State Key Lab Chem & Biol Sensing & Chemometr, Coll Chem & Chem Engn, Inst Biol Technol, Changsha 410082, Peoples R China
关键词
luminescent probes; nanoparticles; quantum dots; metal nanoparticles; dye-doped silica; up-converting phosphors; polymer nanoparticles; fluorescence; bioimaging;
D O I
10.1166/jnn.2004.017
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Bioimaging with luminescent nanoparticle probes have recently attracted widespread interest in biology and medicine. In comparison with commonly used organic dyes, luminescent nanoparticles are better in terms of photostability and sensitivity. These optical features of nanoparticle probes are critical for real time tracking and monitoring of biological events in the cellular level, which may not be accomplished using regular fluorescent dyes. Nanoparticle probes are also shown highly suitable for immunoassay and other diagnostic and therapeutic applications. In this article, we describe a variety of optical nanoparticle probes such as quantum dots, metal nanoparticles, dye-doped nanoparticles etc. for bioimaging applications.
引用
收藏
页码:590 / 599
页数:10
相关论文
共 72 条
[11]   Quantum dot bioconjugates for ultrasensitive nonisotopic detection [J].
Chan, WCW ;
Nie, SM .
SCIENCE, 1998, 281 (5385) :2016-2018
[12]  
Coester CJ, 2000, J MICROENCAPSUL, V17, P187
[13]   Characterization of nanoparticle uptake by endothelial cells [J].
Davda, J ;
Labhasetwar, V .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2002, 233 (1-2) :51-59
[14]   Single-mismatch detection using gold-quenched fluorescent oligonucleotides [J].
Dubertret, B ;
Calame, M ;
Libchaber, AJ .
NATURE BIOTECHNOLOGY, 2001, 19 (04) :365-370
[15]   In vivo imaging of quantum dots encapsulated in phospholipid micelles [J].
Dubertret, B ;
Skourides, P ;
Norris, DJ ;
Noireaux, V ;
Brivanlou, AH ;
Libchaber, A .
SCIENCE, 2002, 298 (5599) :1759-1762
[16]   Selective colorimetric detection of polynucleotides based on the distance-dependent optical properties of gold nanoparticles [J].
Elghanian, R ;
Storhoff, JJ ;
Mucic, RC ;
Letsinger, RL ;
Mirkin, CA .
SCIENCE, 1997, 277 (5329) :1078-1081
[17]   Quantum-dot nanocrystals for ultrasensitive biological labeling and multicolor optical encoding [J].
Gao, XH ;
Chan, WCW ;
Nie, SM .
JOURNAL OF BIOMEDICAL OPTICS, 2002, 7 (04) :532-537
[18]   ADSORPTION OF HORSERADISH-PEROXIDASE, OVOMUCOID AND ANTIIMMUNOGLOBULIN TO COLLOIDAL GOLD FOR INDIRECT DETECTION OF CONCANAVALIN-A, WHEAT-GERM AGGLUTININ AND GOAT ANTIHUMAN IMMUNOGLOBULIN-G ON CELL-SURFACES AT ELECTRON-MICROSCOPIC LEVEL - NEW METHOD, THEORY AND APPLICATION [J].
GEOGHEGAN, WD ;
ACKERMAN, GA .
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1977, 25 (11) :1187-1200
[19]   Sorting fluorescent nanocrystals with DNA [J].
Gerion, D ;
Parak, WJ ;
Williams, SC ;
Zanchet, D ;
Micheel, CM ;
Alivisatos, AP .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (24) :7070-7074
[20]   Synthesis and properties of biocompatible water-soluble silica-coated CdSe/ZnS semiconductor quantum dots [J].
Gerion, D ;
Pinaud, F ;
Williams, SC ;
Parak, WJ ;
Zanchet, D ;
Weiss, S ;
Alivisatos, AP .
JOURNAL OF PHYSICAL CHEMISTRY B, 2001, 105 (37) :8861-8871