A potential role for daptomycin in enterococcal infections: what is the evidence?

被引:66
作者
Canton, Rafael [1 ,2 ,3 ]
Ruiz-Garbajosa, Patricia [1 ,2 ,3 ]
Chaves, Ricardo L. [4 ]
Johnson, Alan P. [5 ]
机构
[1] Hosp Univ Ramon y Cajal, Microbiol Serv, Madrid, Spain
[2] IRYCIS, Madrid, Spain
[3] CIBER Epidemiol & Salud Publ, Madrid, Spain
[4] Novartis Pharma AG, CH-4056 Basel, Switzerland
[5] Hlth Protect Agcy Ctr Infect, Dept Healthcare Associated Infect & Antimicrobial, London NW9 5EQ, England
关键词
Gram-positive bacteria; cyclic lipopeptide antibiotics; nosocomial infections; vancomycin resistance; VANCOMYCIN-RESISTANT ENTEROCOCCI; IN-VITRO ACTIVITY; RETROSPECTIVE CASE SERIES; BLOOD-STREAM INFECTIONS; GRAM-POSITIVE COCCI; STAPHYLOCOCCUS-AUREUS; EXPERIMENTAL ENDOCARDITIS; MULTIDRUG-RESISTANT; CLINICAL-EXPERIENCE; OUTCOMES REGISTRY;
D O I
10.1093/jac/dkq087
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Nosocomial infections caused by enterococci present a challenge for clinicians because treatment options are often limited due to the widespread occurrence of strains resistant to multiple antibiotics, including vancomycin. Daptomycin is a first-in-class cyclic lipopeptide that has proven efficacy for the treatment of Gram-positive infections. Although methicillin-resistant Staphylococcus aureus has been the most prominent target in the clinical development of daptomycin, this agent has demonstrated potent bactericidal activity in enterococcal infection models and has been used for the treatment of enterococcal infections in humans. In recent years, large-scale susceptibility studies have shown that daptomycin is active against > 98% of enterococci tested, irrespective of their susceptibility to other antibacterial agents. This lack of cross-resistance reflects the fact that daptomycin has a mode of action distinct from those of other antibiotics, including glycopeptides. While there are limited data available from randomized controlled trials, extensive clinical experience with daptomycin in enterococcal infections (including bacteraemia, endocarditis, skin and soft tissue infections, bone and joint infections and urinary tract infections) has been reported. This growing body of evidence provides useful insights regarding the efficacy of daptomycin against enterococci in clinical settings.
引用
收藏
页码:1126 / 1136
页数:11
相关论文
共 100 条
[11]  
BADAL R, 2009, 19 EUR C CLIN MICR I
[12]   A febrile neutropenic patient with Enterococcus gallinarum sepsis treated with daptomycin and gentamicin [J].
Barber, Gerard R. ;
Lauretta, Joseph ;
Saez, Ruben .
PHARMACOTHERAPY, 2007, 27 (06) :927-932
[13]  
Beneri Christy A, 2008, Infect Drug Resist, V1, P9
[14]   Linezolid for the treatment of multidrug-resistant, gram-positive infections: Experience from a compassionate-use program [J].
Birmingham, MC ;
Rayner, CR ;
Meagher, AK ;
Flavin, SM ;
Batts, DH ;
Schentag, JJ .
CLINICAL INFECTIOUS DISEASES, 2003, 36 (02) :159-168
[15]   DAPTOMYCIN OR TEICOPLANIN IN COMBINATION WITH GENTAMICIN FOR TREATMENT OF EXPERIMENTAL ENDOCARDITIS DUE TO A HIGHLY GLYCOPEPTIDE-RESISTANT ISOLATE OF ENTEROCOCCUS-FAECIUM [J].
CARON, F ;
KITZIS, MD ;
GUTMANN, L ;
CREMIEUX, AC ;
MAZIERE, B ;
VALLOIS, JM ;
SALEHMGHIR, A ;
LEMELAND, JF ;
CARBON, C .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1992, 36 (12) :2611-2616
[16]   Daptomycin for the treatment of surgical site infections [J].
Chamberlain, Ronald S. ;
Culshaw, Darren L. ;
Donovan, Brian J. ;
Lamp, Kenneth C. .
SURGERY, 2009, 146 (02) :316-324
[17]  
Clinical and Laboratory Standards Institute, 2008, M100S18 CLSI
[18]   Population structure of Enterococcus faecium causing Bacteremia in a Spanish University Hospital:: Setting the scene for a future increase in vancomycin resistance? [J].
Coque, TM ;
Willems, RJL ;
Fortún, J ;
Top, J ;
Diz, S ;
Loza, E ;
Cantón, R ;
Baquero, F .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2005, 49 (07) :2693-2700
[19]   A Balancing Act: Microbe versus Muscle [J].
Cosgrove, Sara E. ;
Corey, G. Ralph .
CLINICAL INFECTIOUS DISEASES, 2009, 49 (02) :181-183
[20]   E. faecalis vancomycin-sensitive enterococcal bacteremia unresponsive to a vancomycin tolerant strain successfully treated with high-dose daptomycin [J].
Cunha, Burke A. ;
Mickail, Nardeen ;
Eisenstein, Lawrence .
HEART & LUNG, 2007, 36 (06) :456-461