Tailoring the genome: the power of genetic approaches

被引：50

作者：

Nagy, A

Perrimon, N

Sandmeyer, S

Plasterk, R

机构：

[1] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada

[2] Univ Toronto, Dept Mol & Med Genet, Toronto, ON, Canada

[3] Harvard Univ, Sch Med, Howard Hughes Med Inst, Dept Genet, Boston, MA 02115 USA

[4] Univ Calif Irvine, Coll Med, Dept Biol Chem, Irvine, CA 92697 USA

[5] Netherlands Inst Dev Biol, Hubrecht Lab, Ctr Biomed Genet, NL-3584 CT Utrecht, Netherlands

来源：

NATURE GENETICS | 2003年 / 33卷 / Suppl 3期

关键词：

D O I：

10.1038/ng1115

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

In the last century, genetics has developed into one of the most powerful tools for addressing basic questions concerning inheritance, development, individual and social operations and death. Here we summarize the current approaches to these questions in four of the most advanced models organisms: Saccharomyces cerevisiae (yeast), Caenorhabditis elegans (worm), Drosophila melanogaster (fly) and Mus muscuius (mouse). The genomes of each of these four models have been sequenced, and all have well developed methods of efficient genetic manipulations.

引用

页码：276 / 284

页数：9

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