Tailoring the genome: the power of genetic approaches

被引：50

作者：

Nagy, A

Perrimon, N

Sandmeyer, S

Plasterk, R

机构：

[1] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada

[2] Univ Toronto, Dept Mol & Med Genet, Toronto, ON, Canada

[3] Harvard Univ, Sch Med, Howard Hughes Med Inst, Dept Genet, Boston, MA 02115 USA

[4] Univ Calif Irvine, Coll Med, Dept Biol Chem, Irvine, CA 92697 USA

[5] Netherlands Inst Dev Biol, Hubrecht Lab, Ctr Biomed Genet, NL-3584 CT Utrecht, Netherlands

来源：

NATURE GENETICS | 2003年 / 33卷 / Suppl 3期

关键词：

D O I：

10.1038/ng1115

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

In the last century, genetics has developed into one of the most powerful tools for addressing basic questions concerning inheritance, development, individual and social operations and death. Here we summarize the current approaches to these questions in four of the most advanced models organisms: Saccharomyces cerevisiae (yeast), Caenorhabditis elegans (worm), Drosophila melanogaster (fly) and Mus muscuius (mouse). The genomes of each of these four models have been sequenced, and all have well developed methods of efficient genetic manipulations.

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页码：276 / 284

页数：9

相关论文

共 120 条

[11]

BRENNER S, 1974, GENETICS, V77, P71

[12] SOMATIC EXPRESSION OF HERPES THYMIDINE KINASE IN MICE FOLLOWING INJECTION OF A FUSION GENE INTO EGGS [J].

BRINSTER, RL ;

CHEN, HY ;

TRUMBAUER, M ;

SENEAR, AW ;

WARREN, R ;

PALMITER, RD .

CELL, 1981, 27 (01) :223-231

[13] LARGE-SCALE ANALYSIS OF GENE-EXPRESSION, PROTEIN LOCALIZATION, AND GENE DISRUPTION SACCHAROMYCES-CEREVISIAE [J].

BURNS, N ;

GRIMWADE, B ;

ROSSMACDONALD, PB ;

CHOI, EY ;

FINBERG, K ;

ROEDER, GS ;

SNYDER, M .

GENES & DEVELOPMENT, 1994, 8 (09) :1087-1105

[14] GREEN FLUORESCENT PROTEIN AS A MARKER FOR GENE-EXPRESSION [J].

CHALFIE, M ;

TU, Y ;

EUSKIRCHEN, G ;

WARD, WW ;

PRASHER, DC .

SCIENCE, 1994, 263 (5148) :802-805

[15] Genotype-based screen for ENU-induced mutations in mouse embryonic stem cells [J].

Chen, YJ ;

Yee, D ;

Dains, K ;

Chatterjee, A ;

Cavalcoli, J ;

Schneider, E ;

Om, J ;

Woychik, RP ;

Magnuson, T .

NATURE GENETICS, 2000, 24 (03) :314-317

[16] Evidence for the stochastic integration of gene trap vectors into the mouse germline [J].

Chowdhury, K ;

Bonaldo, P ;

Torres, M ;

Stoykova, A ;

Gruss, P .

NUCLEIC ACIDS RESEARCH, 1997, 25 (08) :1531-1536

[17] Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways [J].

Clemens, JC ;

Worby, CA ;

Simonson-Leff, N ;

Muda, M ;

Maehama, T ;

Hemmings, BA ;

Dixon, JE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (12) :6499-6503

[18] GENOME LINKING WITH YEAST ARTIFICIAL CHROMOSOMES [J].

COULSON, A ;

WATERSTON, R ;

KIFF, J ;

SULSTON, J ;

KOHARA, Y .

NATURE, 1988, 335 (6186) :184-186

[19]

Craig N., 2002, MOBILE DNA

[20] A protein-protein interaction map of the Caenorhabditis elegans 26S proteasome [J].

Davy, A ;

Bello, P ;

Thierry-Mieg, N ;

Vaglio, P ;

Hitti, J ;

Doucette-Stamm, L ;

Thierry-Mieg, D ;

Reboul, J ;

Boulton, S ;

Walhout, AJM ;

Coux, O ;

Vidal, M .

EMBO REPORTS, 2001, 2 (09) :821-828

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