Bax, Bid and the permeabilization of the mitochondrial outer membrane in apoptosis

被引：172

作者：

Crompton, M ^{[1
]}

机构：

[1] UCL, Dept Biochem & Mol Biol, London WC1E 6BT, England

来源：

CURRENT OPINION IN CELL BIOLOGY | 2000年 / 12卷 / 04期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

D O I：

10.1016/S0955-0674(00)00110-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mitochondria provide a key amplification step in the apoptotic pathway of many cells by releasing apoptogenic proteins into the cytosol. Recent studies have provided insights into how Bax and Bid may operate synergistically to recruit mitochondria into the pathway and how GD3 ganglioside, a metabolite of the sphingomyelin pathway, may also be used. In ischaemic disease, activation of the mitochondrial permeability transition pare may bypass the requirement for these factors.

引用

页码：414 / 419

页数：6

共 45 条

[11] Bax-induced caspase activation and apoptosis via cytochrome c release from mitochondria is inhibitable by Bcl-xL
Finucane, DM
Bossy-Wetzel, E
Waterhouse, NJ
Cotter, TG
Green, DR
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (04) : 2225 - 2233
[12] Regulated targeting of BAX to mitochondria
Goping, IS
Gross, A
Lavoie, JN
Nguyen, M
Jemmerson, R
Roth, K
Korsmeyer, SJ
Shore, GC
[J]. JOURNAL OF CELL BIOLOGY, 1998, 143 (01) : 207 - 215
[13] Role of mitochondria and C-terminal membrane anchor of Bcl-2 in Bax induced growth arrest and mortality in Saccharomyces cerevisiae
Greenhalf, W
Stephan, C
Chaudhuri, B
[J]. FEBS LETTERS, 1996, 380 (1-2) : 169 - 175
[14] Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis
Gross, A
Jockel, J
Wei, MC
Korsmeyer, SJ
[J]. EMBO JOURNAL, 1998, 17 (14) : 3878 - 3885
[15] Bax directly induces release of cytochrome c from isolated mitochondria
Jürgensmeier, JM
Xie, ZH
Deveraux, Q
Ellerby, L
Bredesen, D
Reed, JC
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (09) : 4997 - 5002
[16] Cyclosporin A and its nonimmunosuppressive analogue N-Me-Val-4-cyclosporin A mitigate glucose/oxygen deprivation-induced damage to rat cultured hippocampal neurons
Khaspekov, L
Friberg, H
Halestrap, A
Viktorov, I
Wieloch, T
[J]. EUROPEAN JOURNAL OF NEUROSCIENCE, 1999, 11 (09) : 3194 - 3198
[17] The pro-apoptotic proteins, Bid and Bax, cause a limited permeabilization of the mitochondrial outer membrane that is enhanced by cytosol
Kluck, RM
Esposti, MD
Perkins, G
Renken, C
Kuwana, T
Bossy-Wetzel, E
Goldberg, M
Allen, T
Barber, MJ
Green, DR
Newmeyer, DD
[J]. JOURNAL OF CELL BIOLOGY, 1999, 147 (04) : 809 - 822
[18] Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia
Krajewski, S
Krajewska, M
Ellerby, LM
Welsh, K
Xie, ZH
Deveraux, QL
Salvesen, GS
Bredesen, DE
Rosenthal, RE
Fiskum, G
Reed, JC
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (10) : 5752 - 5757
[19] Apoptogenic ganglioside GD3 directly induces the mitochondrial permeability transition
Kristal, BS
Brown, AM
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (33) : 23169 - 23175
[20] Calcium in ischemic cell death
Kristián, T
Siesjö, BK
[J]. STROKE, 1998, 29 (03) : 705 - 718

← 1 2 3 4 5 →