Flaxseed increased α-linolenic and eicosapentaenoic acid and decreased arachidonic acid in serum and tissues of rat dams and offspring

被引：28

作者：

Wiesenfeld, PW ^{[1
]}

Babu, US ^{[1
]}

Collins, TFX ^{[1
]}

Sprando, R ^{[1
]}

O'Donnell, MW ^{[1
]}

Flynn, TJ ^{[1
]}

Black, T ^{[1
]}

Olejnik, N ^{[1
]}

机构：

[1] US FDA, Ctr Food Safety & Appl Nutr, Laurel, MD 20708 USA

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2003年 / 41卷 / 06期

关键词：

flaxseed; alpha-linolenic acid; fatty acids; pregnant rats;

D O I：

10.1016/S0278-6915(03)00035-8

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The effects of dietary flaxseed (FS), and defatted flaxseed meal (FLM) on serum and tissue fatty acid profiles were investigated. Pregnant Sprague-Dawley rats were fed AIN-93 based diets balanced in calories, fat, nitrogen, and fiber. Diets contained 0, 20%, 40% FS or 13% or 26% FLM by weight. The control, FS and FLM diets differed in linoleic acid to alpha-linolenic acid (ALA) fatty acid ratio. These diets were fed continuously during gestation, suckling period and 8 weeks post-weaning (F-1). FS fatty acids were bioavailable and metabolized by pregnant and F-1 rats. ALA and eicosapentaenoic acid increased; linoleic and arachidonic acid decreased; and docosahexaeonic acid was unchanged in serum, 'gastric milk' and liver of FS and FLM-fed pregnant and F-1 rats. FS more than FLM, changed fatty acids profiles, but FLM and 40% FS significantly reduced serum cholesterol. Dietary 40% FS may have increased oxidative stress as evidenced by a reduction in liver vitamin E. Published by Elsevier Science Ltd.

引用

页码：841 / 855

页数：15

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