Vaccines for Venezuelan equine encephalitis

被引：77

作者：

Paessler, Slobodan ^{[1
]}

Weaver, Scott C.

机构：

[1] Univ Texas Med Branch, Dept Pathol, Ctr Biodef & Emerging Infect Dis, Galveston, TX 77555 USA

来源：

VACCINE | 2009年 / 27卷

关键词：

Vaccines; Togaviridae; Encephalitis; ALPHAVIRUS REPLICON PARTICLES; REGULATORY T-CELLS; GAMMA-DELTA CELLS; VIRUS-INFECTION; SINDBIS VIRUS; ENCEPHALOMYELITIS VIRUS; AIRBORNE CHALLENGE; NONHUMAN-PRIMATES; IN-VITRO; CYTOTOXIC LYMPHOCYTES;

D O I：

10.1016/j.vaccine.2009.07.095

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Arboviruses are capable of causing encephalitis in animals and human population when transmitted by the vector or potentially via infectious aerosol. Recent re-emergence of Venezuelan equine encephalitis virus (VEEV) in South America emphasizes the importance of this pathogen to public health and veterinary medicine. Despite its importance no antivirals or vaccines against VEEV are currently available in the USA. Here we review some of the older and newer approaches aimed at generating a safe and immunogenic vaccine as well as most recent data about the mechanistic of protection in animal models of infection. (C) 2009 Elsevier Ltd. All rights reserved.

引用

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页码：D80 / D85

页数：6

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