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The role of kit-ligand in melanocyte development and epidermal homeostasis

被引：180
作者：
Wehrle-Haller, B [1 ]
机构：
[1] Ctr Med Univ Geneva, Dept Pathol, CH-1211 Geneva 4, Switzerland
来源：
PIGMENT CELL RESEARCH | 2003年 / 16卷 / 03期
关键词：
development; kit-ligand; kit-receptor; melanocyte; migration; neural Crest;
D O I：
10.1034/j.1600-0749.2003.00055.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Kit-ligand (Kitl) also known as steel factor, stem cell factor and mast cell growth factor plays a crucial role in the development and maintenance of the melanocyte lineage in adult skin. Kitl exerts permanent survival, proliferation and migration functions in Kit receptor-expressing melanocytes. A comprehensive overview over the differential roles of Kitl in melanocyte development and homeostasis is provided. I discuss species-specific differences of the Kitl/Kit signalling system, regulation at the transcriptional level and also covering the regulation of cell surface Kitl presentation by cytoplasmic targeting sequences. In addition, recent studies evoked the importance of Kitl misexpression in some hyperpigmented lesions that may open the avenue for Kitl-dependent treatment of pathological skin conditions.
引用
收藏
页码：287 / 296
页数：10
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