The role of kit-ligand in melanocyte development and epidermal homeostasis

被引：180

作者：

Wehrle-Haller, B ^{[1
]}

机构：

[1] Ctr Med Univ Geneva, Dept Pathol, CH-1211 Geneva 4, Switzerland

来源：

PIGMENT CELL RESEARCH | 2003年 / 16卷 / 03期

关键词：

development; kit-ligand; kit-receptor; melanocyte; migration; neural Crest;

D O I：

10.1034/j.1600-0749.2003.00055.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Kit-ligand (Kitl) also known as steel factor, stem cell factor and mast cell growth factor plays a crucial role in the development and maintenance of the melanocyte lineage in adult skin. Kitl exerts permanent survival, proliferation and migration functions in Kit receptor-expressing melanocytes. A comprehensive overview over the differential roles of Kitl in melanocyte development and homeostasis is provided. I discuss species-specific differences of the Kitl/Kit signalling system, regulation at the transcriptional level and also covering the regulation of cell surface Kitl presentation by cytoplasmic targeting sequences. In addition, recent studies evoked the importance of Kitl misexpression in some hyperpigmented lesions that may open the avenue for Kitl-dependent treatment of pathological skin conditions.

引用

页码：287 / 296

页数：10

共 103 条

[11] The carboxyl-terminal valine residues of ProTGF alpha are required for its efficient maturation and intracellular routing
Briley, GP
Hissong, MA
Chiu, ML
Lee, DC
[J]. MOLECULAR BIOLOGY OF THE CELL, 1997, 8 (08) : 1619 - 1631
[12] TRANSMEMBRANE KIT-LIGAND CLEAVAGE DOES NOT REQUIRE A SIGNAL IN THE CYTOPLASMIC DOMAIN AND OCCURS AT A SITE-DEPENDENT ON SPACING FROM THE MEMBRANE
CHENG, HJ
FLANAGAN, JG
[J]. MOLECULAR BIOLOGY OF THE CELL, 1994, 5 (09) : 943 - 953
[13] Conway SJ, 1997, DEVELOPMENT, V124, P505
[14] MAST-CELL GROWTH-FACTOR MAPS NEAR THE STEEL LOCUS ON MOUSE CHROMOSOME-10 AND IS DELETED IN A NUMBER OF STEEL ALLELES
COPELAND, NG
GILBERT, DJ
CHO, BC
DONOVAN, PJ
JENKINS, NA
COSMAN, D
ANDERSON, D
LYMAN, SD
WILLIAMS, DE
[J]. CELL, 1990, 63 (01) : 175 - 183
[15] GENETIC AND STRUCTURAL HOMOLOGY OF STEM-CELL FACTOR AND MACROPHAGE COLONY STIMULATING FACTOR
DOVER, GA
[J]. CELL, 1991, 65 (01) : 9 - 10
[16] THE W-SH AND PH MUTATIONS AFFECT THE C-KIT EXPRESSION PROFILE - C-KIT MISEXPRESSION IN EMBRYOGENESIS IMPAIRS MELANOGENESIS IN W-SH AND PH MUTANT MICE
DUTTLINGER, R
MANOVA, K
BERROZPE, G
CHU, TY
DELEON, V
TIMOKHINA, I
CHAGANTI, RSK
ZELENETZ, AD
BACHVAROVA, RF
BESMER, P
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (09) : 3754 - 3758
[17] DUTTLINGER R, 1993, DEVELOPMENT, V118, P705
[18] A role for a PDZ protein in the early secretory pathway for the targeting of proTGF-α to the cell surface
Fernández-Larrea, J
Merlos-Suárez, A
Ureña, JM
Baselga, J
Arribas, J
[J]. MOLECULAR CELL, 1999, 3 (04) : 423 - 433
[19] Local administration of antisense phosphorothioate oligonucleotides to the c-kit ligand, stem cell factor, suppresses airway inflammation and IL-4 production in a murine model of asthma
Finotto, S
Buerke, M
Lingnau, K
Schmitt, E
Galle, PR
Neurath, MF
[J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2001, 107 (02) : 279 - 286
[20] TRANSMEMBRANE FORM OF THE KIT LIGAND GROWTH-FACTOR IS DETERMINED BY ALTERNATIVE SPLICING AND IS MISSING IN THE SI(D) MUTANT
FLANAGAN, JG
CHAN, DC
LEDER, P
[J]. CELL, 1991, 64 (05) : 1025 - 1035

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