Type 1 interferons and myositis

被引：59

作者：

Greenberg, Steven A. ^{[1
]}

机构：

[1] Brigham & Womens Hosp, Dept Neurol, Div Neuromuscular Dis, Boston, MA 02115 USA

来源：

ARTHRITIS RESEARCH & THERAPY | 2010年 / 12卷

基金：

美国国家卫生研究院;

关键词：

SYSTEMIC-LUPUS-ERYTHEMATOSUS; INDUCIBLE GENE-EXPRESSION; INFLAMMATORY MYOPATHIES; TUBULORETICULAR INCLUSIONS; PERIPHERAL-BLOOD; ALPHA-INTERFERON; DISEASE-ACTIVITY; DERMATOMYOSITIS PATIENTS; LEUKOCYTE INTERFERON; POSITIVE FEEDBACK;

D O I：

10.1186/ar2885

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recent studies suggest a mechanistic role for molecules induced by type 1 interferons in the pathogenesis of some forms of myositis. For dermatomyositis, evidence that these molecules injure myofibers seems especially strong. In the group of disorders known as polymyositis, the study of blood samples suggests a potential role. It is unknown what drives the sustained presence of type 1 interferon-inducible molecules in these diseases, as the type 1 interferons themselves have not been specifically detected along with their downstream biomarkers. Therapeutic development for blockade of IFN alpha is in progress aided by the identification of blood genomic biomarkers.

引用

页数：7

共 39 条

[11] Uncertainties in the pathogenesis of adult dermatomyositis [J].

Greenberg, SA ;

Amato, AA .

CURRENT OPINION IN NEUROLOGY, 2004, 17 (03) :359-364

[12] Proposed immunologic models of the inflammatory myopathies and potential therapeutic implications [J].

Greenberg, Steven A. .

NEUROLOGY, 2007, 69 (21) :2008-2019

[13] Inflammatory myopathies: disease mechanisms [J].

Greenberg, Steven A. .

CURRENT OPINION IN NEUROLOGY, 2009, 22 (05) :516-523

[14]

GRIMLEY PM, 1985, LAB INVEST, V52, P638

[15]

GRIMLEY PM, 1984, CANCER RES, V44, P3480

[16] Open-label trial of anti-TNF-α in dermato- and polymyositis treated concomitantly with methotrexate [J].

Hengstman, G. J. D. ;

De Bleecker, J. L. ;

Feist, E. ;

Vissing, J. ;

Denton, C. P. ;

Manoussakis, M. N. ;

Jensen, H. Slott ;

van Engelen, B. G. M. ;

van den Hoogen, F. H. J. .

EUROPEAN NEUROLOGY, 2008, 59 (3-4) :159-163

[17] IMMUNE INTERFERON IN THE CIRCULATION OF PATIENTS WITH AUTO-IMMUNE DISEASE [J].

HOOKS, JJ ;

MOUTSOPOULOS, HM ;

GEIS, SA ;

STAHL, NI ;

DECKER, JL ;

NOTKINS, AL .

NEW ENGLAND JOURNAL OF MEDICINE, 1979, 301 (01) :5-8

[18] MULTIPLE INTERFERONS IN THE CIRCULATION OF PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS AND VASCULITIS [J].

HOOKS, JJ ;

JORDAN, GW ;

CUPPS, T ;

MOUTSOPOULOS, HM ;

FAUCI, AS ;

NOTKINS, AL .

ARTHRITIS AND RHEUMATISM, 1982, 25 (04) :396-400

[19] Functional assay of type I interferon in systemic lupus erythematosus plasma and association with anti-RNA binding protein autoantibodies [J].

Hua, Jing ;

Kirou, Kyriakos ;

Lee, Christina ;

Crow, Mary K. .

ARTHRITIS AND RHEUMATISM, 2006, 54 (06) :1906-1916

[20]

ISENBERG DA, 1986, CLIN EXP IMMUNOL, V63, P450

← 1 2 3 4 →