Synthesis of (+)-artemisinin and (+)-deoxoartemisinin from arteannuin B and arteannuic acid

被引：49

作者：

Nowak, DM ^{[1
]}

Lansbury, PT ^{[1
]}

机构：

[1] SUNY Buffalo, Dept Chem, Buffalo, NY 14214 USA

来源：

TETRAHEDRON | 1998年 / 54卷 / 3-4期

关键词：

D O I：

10.1016/S0040-4020(97)10286-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(+)-Artemisinin and (+)-Deoxoartemisinin were prepared for the first time from arteannuin B. The synthetic route is short and efficient, making use of the prior art for the final photo-oxygenation/cyclization reaction. A convergent route to each of the above-named products from arteannuic acid is also described. A novel oxidative lactonization reaction was developed for this sequence. (C) 1997 Elsevier Science Ltd. All rights reserved.

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页码：319 / 336

页数：18

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