Oestrogens and spermatogenesis

被引：244

作者：

Carreau, Serge ^{[2
]}

Hess, Rex A. ^{[1
]}

机构：

[1] Univ Illinois, Dept Vet Biosci, Urbana, IL 61802 USA

[2] Univ Caen, Dept Biochem, EA 2608, USC INRA 2006,IFR 146, F-14032 Caen, France

来源：

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES | 2010年 / 365卷 / 1546期

关键词：

testis; oestrogen; spermatogenesis; oestrogen receptor; germ cell; MESSENGER-RIBONUCLEIC-ACID; MALE REPRODUCTIVE-SYSTEM; RAT SERTOLI-CELLS; ALPHA ER-ALPHA; HUMAN EJACULATED SPERMATOZOA; PROTEIN-COUPLED RECEPTOR; ADULT MALE RATS; EFFERENT DUCTULE EPITHELIUM; AROMATASE GENE-EXPRESSION; ACTIVE P450 AROMATASE;

D O I：

10.1098/rstb.2009.0235

中图分类号：

Q [生物科学];

学科分类号：

090105 [作物生产系统与生态工程];

摘要：

The role of oestrogens in male reproductive tract physiology has for a long time been a subject of debate. The testis produces significant amounts of oestrogenic hormones, via aromatase, and oestrogen receptors (ERs)alpha (ESR1) and ER beta (ESR2) are selectively expressed in cells of the testis as well as the epididymal epithelium, depending upon species. This review summarizes the current knowledge concerning the presence and activity of aromatase and ERs in testis and sperm and the potential roles that oestrogens may have in mammalian spermatogenesis. Data show that physiology of the male gonad is in part under the control of a balance of androgens and oestrogens, with aromatase serving as a modulator.

引用

页码：1517 / 1535

页数：19

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