Cathelicidin LL-37: A Multitask Antimicrobial Peptide

被引:181
作者
Bucki, Robert [1 ]
Leszczynska, Katarzyna [2 ]
Namiot, Andrzej [3 ]
Sokolowski, Wojciech [1 ]
机构
[1] Univ Penn, Inst Med & Engn, Vagelos Res Labs 1010, Philadelphia, PA 19104 USA
[2] Med Univ Bialystok, Dept Diagnost Microbiol, Bialystok, Poland
[3] Med Univ Bialystok, Dept Anat, Bialystok, Poland
关键词
Antibacterial agents; Bacteria; Infection; hCAP-18; CYSTIC-FIBROSIS SPUTUM; HOST-DEFENSE PEPTIDES; EPITHELIAL-CELLS; VITAMIN-D; F-ACTIN; SALIVARY-GLANDS; GROWTH-FACTOR; LIPOPOLYSACCHARIDE NEUTRALIZATION; ANTIBIOTIC LL-37/HCAP-18; PSEUDOMONAS-AERUGINOSA;
D O I
10.1007/s00005-009-0057-2
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The antimicrobial peptide LL-37 is the only known member of the cathelicidin family of peptides expressed in humans. LL-37 is a multifunctional host defense molecule essential for normal immune responses to infection and tissue injury. LL-37 peptide is a potent killer of different microorganisms with the ability to prevent immunostimulatory effects of bacterial wall molecules such as lipopolysaccharide and can therefore protect against lethal endotoxemia. Additional reported activities of LL-37 include chemoattractant function, inhibition of neutrophil apoptosis, and stimulation of angiogenesis, tissue regeneration, and cytokine release (e.g. IL-8). Cellular production of LL-37 is affected by multiple factors, including bacterial products, host cytokines, availability of oxygen, and sun exposure through the activation of CAP-18 gene expression by vitamin D-3. At infection sites, the function of LL-37 can be inhibited by charge-driven interactions with DNA and F-actin released from dead neutrophils and other cells lysed as the result of inflammation. A better understanding of LL-37's biological properties is necessary for its possible therapeutic application for immunomodulatory purposes as well as in treating bacterial infection.
引用
收藏
页码:15 / 25
页数:11
相关论文
共 96 条
[61]   An antimicrobial cathelicidin peptide, human CAP18/LL-37, suppresses neutrophil apoptosis via the activation of formyl-peptide receptor-like 1 and P2X7 [J].
Nagaoka, Isao ;
Tamura, Hiroshi ;
Hirata, Michimasa .
JOURNAL OF IMMUNOLOGY, 2006, 176 (05) :3044-3052
[62]   The roles of cathelicidin LL-37 in immune defences and novel clinical applications [J].
Nijnik, Anastasia ;
Hancock, Robert E. W. .
CURRENT OPINION IN HEMATOLOGY, 2009, 16 (01) :41-47
[63]   Antimicrobial peptides human β-defensins stimulate epidermal keratinocyte migration, proliferation and production of proinflammatory cytokines and chemokines [J].
Niyonsaba, Francois ;
Ushio, Hiroko ;
Nakano, Nobuhiro ;
Ng, William ;
Sayama, Koji ;
Hashimoto, Koji ;
Nagaoka, Isao ;
Okumura, Ko ;
Ogawa, Hideoki .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2007, 127 (03) :594-604
[64]   Fungal allergens induce cathelicidin LL-37 expression in chronic rhinosinusitis patients in a nasal explant model [J].
Ooi, Eng Hooi ;
Wormald, Peter-John ;
Carney, A. Simon ;
James, Craig Lloyd ;
Tan, Lor Wai .
AMERICAN JOURNAL OF RHINOLOGY, 2007, 21 (03) :367-372
[65]   Human host defense peptide LL-37 prevents bacterial biofilm formation [J].
Overhage, Joerg ;
Campisano, Andrea ;
Bains, Manjeet ;
Torfs, Ellen C. W. ;
Rehm, Bernd H. A. ;
Hancock, Robert E. W. .
INFECTION AND IMMUNITY, 2008, 76 (09) :4176-4182
[66]   Collagen Synthesis Is Suppressed in Dermal Fibroblasts by the Human Antimicrobial Peptide LL-37 [J].
Park, Hyun Jeong ;
Cho, Dae Ho ;
Kim, Hee Jung ;
Lee, Jun Young ;
Cho, Baik Kee ;
Bang, Sa Ik ;
Song, Sang Yong ;
Yamasaki, Kenshi ;
Di Nardo, Anna ;
Gallo, Richard L. .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2009, 129 (04) :843-850
[67]   Critical role of HIF-1α in keratinocyte defense against bacterial infection [J].
Peyssonnaux, Carole ;
Boutin, Adam T. ;
Zinkernagel, Annelies S. ;
Datta, Vivekanand ;
Nizet, Victor ;
Johnson, Randall S. .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2008, 128 (08) :1964-1968
[68]   Modulation by LL-37 of the responses of salivary glands to purinergic agonists [J].
Pochet, Stephanie ;
Tandel, Severine ;
Querriere, Stephanie ;
Tre-Hardy, Marie ;
Garcia-Marcos, Mikel ;
De Lorenzi, Manuela ;
Vandenbranden, Michel ;
Marino, Aida ;
Devleeschouwer, Michel ;
Dehaye, Jean-Paul .
MOLECULAR PHARMACOLOGY, 2006, 69 (06) :2037-2046
[69]   Expression of cathelicidin LL-37 during Mycobacterium tuberculosis infection in human alveolar macrophages, monocytes, neutrophils, and epithelial cells [J].
Rivas-Santiago, Bruno ;
Hernandez-Pando, Rogelio ;
Carranza, Claudia ;
Juarez, Esmeralda ;
Contreras, Juan Leon ;
Aguilar-Leon, Diana ;
Torres, Martha ;
Sada, Eduardo .
INFECTION AND IMMUNITY, 2008, 76 (03) :935-941
[70]   Endotoxin (lipopolysaccharide) neutralization by innate immunity host-defense peptides - Peptide properties and plausible modes of action [J].
Rosenfeld, Y ;
Papo, N ;
Shai, Y .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (03) :1636-1643