Corpse clearance defines the meaning of cell death

被引：1177

作者：

Savill, J ^{[1
]}

Fadok, V

机构：

[1] Univ Edinburgh, Royal Infirm, Dept Clin & Surg Sci Internal Med, MRC,Ctr Inflammat Res, Edinburgh EH3 9YW, Midlothian, Scotland

[2] Natl Jewish Med & Res Ctr, Dept Pediat, Cell Biol Program, Denver, CO 80206 USA

来源：

NATURE | 2000年 / 407卷 / 6805期

关键词：

D O I：

10.1038/35037722

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

While philosophers seek the meaning of life, cell biologists are becoming ever more interested in the meaning of death. Apoptosis marks unwanted cells with 'eat me' signals that direct recognition, engulfment and degradation by phagocytes. Far from being the end of the story, these clearance events allow scavenger cells to confer meaning upon cell death. But if the phagocytic 'spin doctors' receive or transmit the wrong messages, trouble ensues.

引用

页码：784 / 788

页数：5

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