Laser speckle contrast imaging of collateral blood flow during acute ischemic stroke

被引：97

作者：

Armitage, Glenn A.

Todd, Kathryn G. ^{[2
]}

Shuaib, Ashfaq ^{[3
]}

Winship, Ian R. ^{[1
,2
]}

机构：

[1] Univ Alberta, Dept Psychiat, Ctr Neurosci, Edmonton, AB T6G 2G3, Canada

[2] Univ Alberta, Dept Psychiat, Neurochem Res Unit, Edmonton, AB T6G 2G3, Canada

[3] Univ Alberta, Dept Med, Div Neurol, Edmonton, AB T6G 2G3, Canada

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 2010年 / 30卷 / 08期

关键词：

animal models; cerebral blood flow; embolic stroke; focal ischemia; neuroprotection; pial vessels; REPERFUSION; FLOWMETRY; OCCLUSION;

D O I：

10.1038/jcbfm.2010.73

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Collateral vasculature may provide an alternative route for blood flow to reach the ischemic tissue and partially maintain oxygen and nutrient support during ischemic stroke. However, much about the dynamics of stroke-induced collateralization remains unknown. In this study, we used laser speckle contrast imaging to map dynamic changes in collateral blood flow after middle cerebral artery occlusion in rats. We identified extensive anastomatic connections between the anterior and middle cerebral arteries that develop after vessel occlusion and persist for 24 hours. Augmenting blood flow through these persistent yet dynamic anastomatic connections may be an important but relatively unexplored avenue in stroke therapy. Journal of Cerebral Blood Flow & Metabolism (2010) 30, 1432-1436; doi: 10.1038/jcbfm.2010.73; published online 2 June 2010

引用

页码：1432 / 1436

页数：5

共 15 条

[1] Laser speckle flowmetry for the study of cerebrovascular physiology in normal and ischemic mouse cortex
Ayata, C
Dunn, AK
Gursoy-Özdemir, Y
Huang, ZH
Boas, DA
Moskowitz, MA
[J]. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2004, 24 (07) : 744 - 755
[2] Impact of collateral flow on tissue fate in acute ischaemic stroke
Bang, O. Y.
Saver, J. L.
Buck, B. H.
Alger, J. R.
Starkman, S.
Ovbiagele, B.
Kim, D.
Jahan, R.
Duckwiler, G. R.
Yoon, S. R.
Vinuela, F.
Liebeskind, D. S.
[J]. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2008, 79 (06) : 625 - 629
[3] Can laser speckle flowmetry be made a quantitative tool?
Duncan, Donald D.
Kirkpatrick, Sean J.
[J]. JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION, 2008, 25 (08) : 2088 - 2094
[4] Dynamic imaging of cerebral blood flow using laser speckle
Dunn, AK
Bolay, T
Moskowitz, MA
Boas, DA
[J]. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2001, 21 (03) : 195 - 201
[5] Pharmacological approaches to acute ischaemic stroke: reperfusion certainly, neuroprotection possibly
Green, A. R.
[J]. BRITISH JOURNAL OF PHARMACOLOGY, 2008, 153 : S325 - S338
[6] Pathophysiology and therapy of experimental stroke
Konstantin-Alexander Hossmann
[J]. Cellular and Molecular Neurobiology, 2006, 26 (7) : 1057 - 1083
[7] Two-Photon Imaging during Prolonged Middle Cerebral Artery Occlusion in Mice Reveals Recovery of Dendritic Structure after Reperfusion
Li, Ping
Murphy, Timothy H.
[J]. JOURNAL OF NEUROSCIENCE, 2008, 28 (46) : 11970 - 11979
[8] Collaterals in acute stroke: Beyond the clot
Liebeskind, DS
[J]. NEUROIMAGING CLINICS OF NORTH AMERICA, 2005, 15 (03) : 553 - +
[9] Collateral circulation
Liebeskind, DS
[J]. STROKE, 2003, 34 (09) : 2279 - 2284
[10] NOOR R, 2009, J NEUROIMAGING 1103

← 1 2 →