RETRACTED: Granisetron reduces vomiting after strabismus surgery and tonsillectomy in children (Retracted article. See vol. 59, pg. 1172, 2012)

被引:34
作者
Fujii, Y [1 ]
Tanaka, H [1 ]
Toyooka, H [1 ]
机构
[1] TORIDE KYODO GEN HOSP, DEPT ANAESTHESIOL, TORIDE, IBARAKI 302, JAPAN
来源
CANADIAN JOURNAL OF ANAESTHESIA-JOURNAL CANADIEN D ANESTHESIE | 1996年 / 43卷 / 01期
关键词
anaesthesia; paediatric; complications; vomiting; antiemetics; granisetron; surgery; strabismus repair; tonsillectomy;
D O I
10.1007/BF03015955
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Purpose: To evaluate the antiemetic efficacy of granisetron, a selective 5-hydroxytryptamine type 3 receptor antagonist on postoperative vomiting in children undergoing general anaesthesia for strabismus repair and tonsillectomy with or without adenoidectomy. Methods: In a randomized, placebo-controlled, double-blind study, fifty patients, 4-10 yr of age, were given a single dose of either placebo (saline, n = 25) or granisetron (40 mu g . kg(-1), n = 25) iv over 2-5 min after the induction of anaesthesia and prior to the surgical procedure. Postoperatively, during the first 24 hr after anaesthesia, the frequencies of retching and vomiting were recorded. Results: There were no differences between the two groups with regard to patient characteristics, surgical procedures and anaesthetic or postoperative management. The incidence of retching was 36% and 12% after administration of placebo or granisetron, respectively (P < 0.05); the corresponding frequencies of vomiting were 32% and 8% (P < 0.05). Four children who had received placebo required another rescue antiemetic drug, whereas none who had received granisetron needed this agent. Conclusion: Granisetron is effective in the prevention of retching and vomiting after strabismus repair and tonsillectomy in paediatric patients.
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页码:35 / 38
页数:4
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