共 13 条
RETRACTED: Granisetron reduces vomiting after strabismus surgery and tonsillectomy in children (Retracted article. See vol. 59, pg. 1172, 2012)
被引:34
作者:
Fujii, Y
[1
]
Tanaka, H
[1
]
Toyooka, H
[1
]
机构:
[1] TORIDE KYODO GEN HOSP, DEPT ANAESTHESIOL, TORIDE, IBARAKI 302, JAPAN
来源:
CANADIAN JOURNAL OF ANAESTHESIA-JOURNAL CANADIEN D ANESTHESIE
|
1996年
/
43卷
/
01期
关键词:
anaesthesia;
paediatric;
complications;
vomiting;
antiemetics;
granisetron;
surgery;
strabismus repair;
tonsillectomy;
D O I:
10.1007/BF03015955
中图分类号:
R614 [麻醉学];
学科分类号:
100217 ;
摘要:
Purpose: To evaluate the antiemetic efficacy of granisetron, a selective 5-hydroxytryptamine type 3 receptor antagonist on postoperative vomiting in children undergoing general anaesthesia for strabismus repair and tonsillectomy with or without adenoidectomy. Methods: In a randomized, placebo-controlled, double-blind study, fifty patients, 4-10 yr of age, were given a single dose of either placebo (saline, n = 25) or granisetron (40 mu g . kg(-1), n = 25) iv over 2-5 min after the induction of anaesthesia and prior to the surgical procedure. Postoperatively, during the first 24 hr after anaesthesia, the frequencies of retching and vomiting were recorded. Results: There were no differences between the two groups with regard to patient characteristics, surgical procedures and anaesthetic or postoperative management. The incidence of retching was 36% and 12% after administration of placebo or granisetron, respectively (P < 0.05); the corresponding frequencies of vomiting were 32% and 8% (P < 0.05). Four children who had received placebo required another rescue antiemetic drug, whereas none who had received granisetron needed this agent. Conclusion: Granisetron is effective in the prevention of retching and vomiting after strabismus repair and tonsillectomy in paediatric patients.
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页码:35 / 38
页数:4
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