Cytokine production by islets in health and diabetes: cellular origin, regulation and function

被引：172

作者：

Donath, Marc Y. ^{[1
]}

Boeni-Schnetzler, Marianne ^{[1
]}

Ellingsgaard, Helga ^{[1
]}

Halban, Philippe A. ^{[2
]}

Ehses, Jan A. ^{[3
,4
]}

机构：

[1] Univ Zurich Hosp, Clin Endocrinol & Diabet, Ctr Integrated Human Physiol, CH-8091 Zurich, Switzerland

[2] Univ Geneva, Dept Genet Med & Dev, CH-1211 Geneva 4, Switzerland

[3] Univ British Columbia, Fac Med, Dept Surg, Vancouver, BC V5Z 4H4, Canada

[4] Child & Family Res Inst, Vancouver, BC V5Z 4H4, Canada

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2010年 / 21卷 / 05期

关键词：

PANCREATIC-BETA-CELLS; NF-KAPPA-B; STIMULATED-INSULIN-SECRETION; NECROSIS-FACTOR-ALPHA; PRO-INFLAMMATORY CYTOKINES; CHRONIC OXIDATIVE STRESS; SATURATED FATTY-ACIDS; GENE-EXPRESSION; EXTRACELLULAR-MATRIX; GLUCOSE TOXICITY;

D O I：

10.1016/j.tem.2009.12.010

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Islets produce a variety of cytokines and chemokines in response to physiologic and pathologic stimulation by nutrients. The cellular source of these inflammatory mediators includes alpha-, beta-, endothelial-, ductal- and recruited immune cells. Islet-derived cytokines promote alpha- and beta-cell adaptation and repair in the short term. Eventually, chronic metabolic stress can induce a deleterious autoinflammatory process in islets leading to insulin secretion failure and type 2 diabetes. Understanding the specific role of islet derived cytokines and chemokines has opened the door to targeted clinical interventions aimed at remodeling islet inflammation from destruction to adaptation. In this article, we review the islet cellular origin of various cytokines and chemokines and describe their regulation and respective roles in physiology and diabetes.

引用

页码：261 / 267

页数：7

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