Sugar-substituted 2-azetidinones as cholesterol absorption inhibitors

被引：55

作者：

Vaccaro, WD ^{[1
]}

Sher, R ^{[1
]}

Davis, HR ^{[1
]}

机构：

[1] Schering Plough Corp, Res Inst, Kenilworth, NJ 07033 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 01期

关键词：

D O I：

10.1016/S0960-894X(97)10185-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The asymmetric synthesis of a glucuronide conjugate of the 2-azetidinone cholesterol absorption inhibitor Sch 48461 was accomplished to confirm the structure of a metabolite isolated from in vivo sources. Key features of this article include the asymmetric synthesis of 2-azetidinones by Evan's chiral oxazolidinone methodology and glucuronide formation by a Mitsunobu protocol. (C) 1997 Elsevier Science Ltd. All rights reserved.

引用

页码：35 / 40

页数：6

共 18 条

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