Thrombotic Microangiopathies: Multimers, Metalloprotease, and Beyond

被引：18

作者：

Moake, Joel ^{[1
]}

机构：

[1] Rice Univ, Houston, TX 77251 USA

来源：

CTS-CLINICAL AND TRANSLATIONAL SCIENCE | 2009年 / 2卷 / 05期

关键词：

TTP; HUS; other thrombotic microangiopathies; VON-WILLEBRAND-FACTOR; FACTOR-CLEAVING PROTEASE; HEMOLYTIC-UREMIC SYNDROME; FACTOR-H-AUTOANTIBODIES; VONWILLEBRAND-FACTOR MULTIMERS; PLATELET GLYCOPROTEIN-IB; THROMBOCYTOPENIC PURPURA; ENDOTHELIAL-CELLS; AURINTRICARBOXYLIC ACID; DEFICIENT ACTIVITY;

D O I：

10.1111/j.1752-8062.2009.00142.x

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The pathophysiology of various types of thrombotic microangiopathies is coming progressively into focus. Therapeutic advances are likely to follow at a quickening pace. This discussion focuses on thrombotic thrombocytopenic purpura (TTP), the hemolytic-uremic syndrome (HUS), thrombotic microangiopathies associated with transplantation-immunosuppression or anti-angiogenesis therapy, and the preeclampsia/hemolysis-elevated liver enzymes and low platelets syndrome (HELLP).

引用

收藏

页码：366 / 373

页数：8

相关论文

共 61 条

[1] Ultralarge multimers of von Willebrand factor form spontaneous high-strength bonds with the platelet glycoprotein Ib-IX complex:: studies using optical tweezers [J].

Arya, M ;

Anvari, B ;

Romo, GM ;

Cruz, MA ;

Dong, JF ;

McIntire, LV ;

Moake, JL ;

López, JA .

BLOOD, 2002, 99 (11) :3971-3977

[2] The distal carboxyl-terminal domains of ADAMTS13 are required for regulation of in vivo thrombus formation [J].

Banno, Fumiaki ;

Chauhan, Anil K. ;

Kokame, Koichi ;

Yang, Jin ;

Miyata, Shigeki ;

Wagner, Denisa D. ;

Miyata, Toshiyuki .

BLOOD, 2009, 113 (21) :5323-5329

[3] Thrombotic thrombocytopenic purpura associated with clopidogrel. [J].

Bennett, CL ;

Connors, JM ;

Carwile, JM ;

Moake, JL ;

Bell, WR ;

Tarantolo, SR ;

McCarthy, LJ ;

Sarode, R ;

Hatfield, AJ ;

Feldman, MD ;

Davidson, CJ ;

Tsai, HM .

NEW ENGLAND JOURNAL OF MEDICINE, 2000, 342 (24) :1773-1777

[4] Thrombotic thrombocytopenic purpura associated with ticlopidine - A review of 60 cases [J].

Bennett, CL ;

Weinberg, PD ;

Rozenberg-Ben-Dror, K ;

Yarnold, PR ;

Kwaan, HC ;

Green, D .

ANNALS OF INTERNAL MEDICINE, 1998, 128 (07) :541-544

[5] Platelets adhered to endothelial cell-bound ultra-large von Willebrand factor strings support leukocyte tethering and rolling under high shear stress [J].

Bernardo, A ;

Ball, C ;

Nolasco, L ;

Choi, H ;

Moake, JL ;

Dong, JF .

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2005, 3 (03) :562-570

[6] Effects of inflammatory cytokines on the release and cleavage of the endothelial cell-derived ultralarge von Willebrand factor multimers under flow [J].

Bernardo, A ;

Ball, C ;

Nolasco, L ;

Moake, JF ;

Dong, JF .

BLOOD, 2004, 104 (01) :100-106

[7] Von Willebrand factor-cleaving protease (ADAMTS13) in thrombocytopenic disorders:: a severely deficient activity is specific for thrombotic thrombocytopenic purpura [J].

Bianchi, V ;

Robles, R ;

Alberio, L ;

Furlan, M ;

Lämmle, B .

BLOOD, 2002, 100 (02) :710-713

[8] Thrombotic microangiopathy secondary to VEGF pathway inhibition by sunitinib [J].

Bollee, Guillaume ;

Patey, Natacha ;

Cazajous, Geraldine ;

Robert, Caroline ;

Goujon, Jean-Michel ;

Fakhouri, Fadi ;

Bruneval, Patrick ;

Noel, Laure-Helene ;

Knebelmann, Bertrand .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2009, 24 (02) :682-685

[9] Complement dysregulation in haemolytic uraemic syndrome [J].

Bonnardeaux, A ;

Pichette, V .

LANCET, 2003, 362 (9395) :1514-1515

[10] Progressive multifocal leukoencephalopathy after rituximab therapy in HIV-negative patients: a report of 57 cases from the Research on Adverse Drug Events and Reports project [J].

Carson, Kenneth R. ;

Evens, Andrew M. ;

Richey, Elizabeth A. ;

Habermann, Thomas M. ;

Focosi, Daniele ;

Seymour, John F. ;

Laubach, Jacob ;

Bawn, Susie D. ;

Gordon, Leo I. ;

Winter, Jane N. ;

Furman, Richard R. ;

Vose, Julie M. ;

Zelenetz, Andrew D. ;

Mamtani, Ronac ;

Raisch, Dennis W. ;

Dorshimer, Gary W. ;

Rosen, Steven T. ;

Muro, Kenji ;

Gottardi-Littell, Numa R. ;

Talley, Robert L. ;

Sartor, Oliver ;

Green, David ;

Major, Eugene O. ;

Bennett, Charles L. .

BLOOD, 2009, 113 (20) :4834-4840

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