Effects of a urinary factor from women in early pregnancy on HIV-1, SIV and associated disease

被引：55

作者：

Lunardi-Iskandar, Y

Bryant, JL

Blattner, WA

Hung, CL

Flamand, L

Gill, P

Hermans, P

Birken, S

Gallo, RC

机构：

[1] Univ Maryland, Inst Human Virol, Baltimore, MD 21201 USA

[2] Adv Biosci Labs Inc, Kensington, MD 20895 USA

[3] Univ So Calif, Sch Med, Los Angeles, CA 90033 USA

[4] Univ Libre Bruxelles, CHU St Pierre Hosp, Dept Malad Infect, B-1000 Brussels, Belgium

[5] Columbia Univ Coll Phys & Surg, New York, NY 10032 USA

来源：

NATURE MEDICINE | 1998年 / 4卷 / 04期

关键词：

D O I：

10.1038/nm0498-428

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effects of clinical grade crude preparations of human chorionic gonadotropin (hCG) on Kaposi's sarcoma, HIV, SIV and hematopoiesis were examined in vitro and in vivo. In contrast to previous studies, we report that the antiviral activity of hCG associated factors is not due to the native hCG heterodimer, including its purified subunits or its major degradation product, the beta-core. Using gel permeation chromatography of the clinical grade hCC and urine concentrates from pregnant women, we demonstrate that an as yet unidentified hCC associated factor (HAF) with anti-HIV, anti-SIV, anti-KS and pro-hematopoietic activities elutes as two peaks corresponding to 15-30 kDa and 2-4 kDa.

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收藏

页码：428 / 434

页数：7

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