Influence of exon duplication on intron and exon phase distribution

被引：31

作者：

Fedorov, A

Fedorova, L

Starshenko, V

Filatov, V

Grigor'ev, E

机构：

[1] Russian Acad Sci, Inst Mol Genet, Dept Mol Basis Human Genet, Moscow 123182, Russia

[2] Univ Sussex, IRC, Sussex Ctr Neurosci, Brighton BN1 9QG, E Sussex, England

[3] Russian Acad Sci, VA Engelhardt Mol Biol Inst, Lab Isotop Res, Moscow 117984, Russia

[4] Ind Inst, Lab Nonlinear Opt Frequency Convers, UA-330006 Zaporozhe, Ukraine

[5] Russian Acad Sci, Inst Mol Genet, Dept Biopolymer Funct & Struct Res, Moscow 123182, Russia

来源：

JOURNAL OF MOLECULAR EVOLUTION | 1998年 / 46卷 / 03期

关键词：

human genes; exon/intron gene structure; intron phase order; exon shuffling evolution; gene;

D O I：

10.1007/PL00006302

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nonrandomness in the intron and exon phase distributions in a sample of 305 human genes has been found and analyzed. It was shown that exon duplications had a significant effect on the exon phase nonrandomness, All of the nonrandomness is probably due to both the processes of exon duplication and shuffling, A quantitative estimation of exon duplications in the human genome and their influence on the intron and exon phase distributions has been analyzed. According to our estimation, the proportion of duplicated exons in the human genome constitutes at least 6% of the total, Generalizing the particular case of exon duplication to the more common event of exon shuffling, we modeled and analyzed the influence of exon shuffling on intron phase distribution.

引用

页码：263 / 271

页数：9

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