Delayed gastric emptying by Helicobacter pylori lipopolysaccharide in conscious rats

被引：36

作者：

Okumura, T ^{[1
]}

Shoji, E

Takahashi, N

Wakebe, H

Imagawa, K

Kikuchi, M

Kohgo, Y

机构：

[1] Asahikawa Med Coll, Dept Internal Med 3, Asahikawa, Hokkaido 078, Japan

[2] Otsuka Pharmaceut Co Ltd, Microbiol Res Inst, Tokushima 77101, Japan

来源：

DIGESTIVE DISEASES AND SCIENCES | 1998年 / 43卷 / 01期

关键词：

Helicobacter pylori; lipopolysaccharide; gastric emptying;

D O I：

10.1023/A:1018828105226

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The present study was carried out to investigate the possibility that lipopolysaccharide deprived from Helicobacter pylori may alter gastric motility. To address the question, we examined the effect of H. pylori lipopolysaccharide on gastric emptying in conscious rats. Gastric emptying was evaluated by the phenol red method. Time-course and dose-related effects of intraperitoneal administration of H. pylori lipopolysaccharide were investigated. Intraperitoneal injection of H. pylori lipopolysaccharide significantly suppressed gastric emptying of a liquid meal in a dose-dependent manner. The inhibitory action of H. pylori lipopolysaccharide was observed 2, 4, 8, or 12 hr after the injection. These results suggest for the first time that H. pylori lipopolysaccharide may suppress gastric emptying in a long-lasting fashion. It is also suggested that H. pylori may influence gastric function through its cell wall structure named lipopolysaccharide.

引用

页码：90 / 94

页数：5

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