α-mannosyl clusters scaffolded on azamacrocycles:: Synthesis and inhibitory properties in the adhesion of type 1 fimbriated Escherichia coli to guinea pig erythrocytes

被引：33

作者：

König, B

Fricke, T

Wassmann, A

Krallmann-Wenzel, U

Lindhorst, TK

机构：

[1] Univ Hamburg, Inst Organ Chem, D-20146 Hamburg, Germany

[2] Forschungszentrum Borstel, D-23845 Borstel, Germany

[3] Gesell Biotechnol Forsch GmbH, D-38124 Braunschweig, Germany

[4] Tech Univ Braunschweig, Inst Organ Chem, D-38106 Braunschweig, Germany

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 16期

关键词：

macrocycles; glycosides; isothiocyanates; supramolecular chemistry;

D O I：

10.1016/S0040-4039(98)00248-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of azamacrocycles, such as la and Ib, with acetyl-protected alpha-D-mannosyl isothiocyanate yields thiourea-bridged tetravalent glycoclusters 3 as novel neoglycoconjugates in one step The deprotected compounds 4 showed significant inhibition of the adhesion of type 1 fimbriated Escherichia coli to Guinea pig erythrocytes. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：2307 / 2310

页数：4

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