Design of copper DNA intercalators with leishmanicidal activity

被引：173

作者：

Navarro, M

Cisneros-Fajardo, EJ

Sierralta, A

Fernández-Mestre, M

Silva, P

Arrieche, D

Marchán, E

机构：

[1] Inst Venezolano Invest Cient, Ctr Quim, Caracas 1020A, Venezuela

[2] Inst Venezolano Invest Cient, Ctr Med Expt, Caracas 1020A, Venezuela

[3] Inst Venezolano Invest Cient, Ctr Fis, Caracas 1020A, Venezuela

[4] Univ Oriente, Inst Invest Biomed & Ciencias Aplicadas, Cumana, Venezuela

来源：

JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY | 2003年 / 8卷 / 04期

关键词：

copper polypyridyl complexes; DNA; metallointercalators; Leishmania braziliensis;

D O I：

10.1007/s00775-002-0427-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The complexes [Cu(dppz)(NO3)]NO3 (1), [Cu(dppz)(2)(NO3)]NO3 (2), [Cu(dpq)(NO3)]NO3 (3), and [Cu(dpq)(2)(NO3)]NO3 (4) were synthesized and characterized by elemental analysis, FAB-mass spectrometry, EPR, UV, and IR spectroscopies, and molar conductivity. DNA interaction studies showed that intercalation is an important way of interacting with DNA for these complexes. The biological activity of these copper complexes was evaluated on Leishmania braziliensis promastigotes, and the results showed leishmanicidal activity. Preliminary ultrastructural studies with the most active complex (2) at 1 h revealed parasite swelling and binucleated cells. This finding suggests that the leishmanicidal activity of the copper complexes could be associated with their interaction with the parasitic DNA.

引用

页码：401 / 408

页数：8

共 33 条

[1] Efficient copper (II)-mediated nuclease activity of ortho-quinacridines
Baudoin, O
Teulade-Fichou, MP
Vigneron, JP
Lehn, JM
[J]. CHEMICAL COMMUNICATIONS, 1998, (21) : 2349 - 2350
[2] Brown J. R., 1987, Chemotherapy of Tropical Diseases. The problems and the challenge (Critical Reports on Applied Chemistry Vol. 21)., P72
[3] Co-ordination properties of 1,10-phenanthroline-5,6-dione towards group 4 and 5 metals in low and high oxidation states
Calderazzo, F
Marchetti, F
Pampaloni, G
Passarelli, V
[J]. JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 1999, (24): : 4389 - 4396
[4] STUDIES ON INTERACTION OF ANTHRACYCLINE ANTIBIOTICS AND DEOXYRIBONUCLEIC-ACID - EQUILIBRIUM BINDING-STUDIES ON INTERACTION OF DAUNOMYCIN WITH DEOXYRIBONUCLEIC-ACID
CHAIRES, JB
DATTAGUPTA, N
CROTHERS, DM
[J]. BIOCHEMISTRY, 1982, 21 (17) : 3933 - 3940
[5] A 1H NMR study of the DNA binding of ruthenium(II) polypyridyl complexes
Collins, JG
Sleeman, AD
Aldrich-Wright, JR
Greguric, I
Hambley, TW
[J]. INORGANIC CHEMISTRY, 1998, 37 (13) : 3133 - 3141
[6] DERIVATIVES OF 1,10-PHENANTHROLINE-5,6-QUINONE
DICKESON, JE
SUMMERS, LA
[J]. AUSTRALIAN JOURNAL OF CHEMISTRY, 1970, 23 (05) : 1023 - &
[7] EKKILA KE, 1999, CHEM REV, V99, P2777
[8] TRYPANOCIDAL AND ANTITUMOUR ACTIVITY OF PLATINUM-METAL AND PLATINUM-METAL-DRUG DUAL-FUNCTION COMPLEXES
FARRELL, NP
WILLIAMSON, J
MCLAREN, DJM
[J]. BIOCHEMICAL PHARMACOLOGY, 1984, 33 (07) : 961 - 971
[9] MOLECULAR LIGHT SWITCH FOR DNA - RU(BPY)2(DPPZ)2+
FRIEDMAN, AE
CHAMBRON, JC
SAUVAGE, JP
TURRO, NJ
BARTON, JK
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (12) : 4960 - 4962
[10] USE OF CONDUCTIVITY MEASUREMENTS IN ORGANIC SOLVENTS FOR CHARACTERISATION OF COORDINATION COMPOUNDS
GEARY, WJ
[J]. COORDINATION CHEMISTRY REVIEWS, 1971, 7 (01) : 81 - &

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