Synthesis of oligoribonucleotides containing 4-thiouridine using the convertible nucleoside approach and the 1-(2-fluorophenyl)-4-methoxypiperidin-4-yl group

被引：5

作者：

Aviñó, A ^{[1
]}

García, RG ^{[1
]}

Eritja, R ^{[1
]}

机构：

[1] CSIC, Inst Mol Biol, E-08034 Barcelona, Spain

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2004年 / 23卷 / 11期

关键词：

4-thiouridine; oligonucleotides; RNA;

D O I：

10.1081/NCN-200034044

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Oligoribonucleotides containing 4-thiouridine were prepared using the Fpmp group for protection of the 2'-OH. Two uridine derivatives with the 1,2,4-triazolyl and the 2-nitrophenyl groups at position 4 were used to obtain 4-thiouridine by postsynthetic substitution with sodium hydrogen sulfide. Both uridine derivatives allow the preparation of the desired oligonucleotides in good yields.

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页码：1767 / 1777

页数：11

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