Dynamic kinetic resolution of allylic alcohols mediated by ruthenium- and lipase-based catalysts

被引：97

作者：

Lee, D ^{[1
]}

Huh, EA ^{[1
]}

Kim, MJ ^{[1
]}

Jung, HM ^{[1
]}

Koh, JH ^{[1
]}

Park, J ^{[1
]}

机构：

[1] Pohang Univ Sci & Technol, Dept Chem, Div Mol & Life Sci, Pohang 790784, Kyungbuk, South Korea

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 15期

关键词：

D O I：

10.1021/ol006159y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] An enzyme-metal combo reaction has been developed for the dynamic kinetic resolution of allylic alcohols in which racemic substrates are transformed by a lipase and a ruthenium complex in the presence of an acyl donor to allylic acetates of high optical purity in over 80% yield.

引用

页码：2377 / 2379

页数：3