Diastereoselective synthesis of 2-monosubstituted and 2,6-disubstituted piperidines

被引：21

作者：

Abrunhosa-Thomas, Isabelle ^{[1
]}

Roy, Olivier ^{[1
]}

Barra, Marielle ^{[1
]}

Besset, Tatiana ^{[1
]}

Chalard, Pierre ^{[1
]}

Troin, Yves ^{[1
]}

机构：

[1] Univ Clermont Ferrand, Ecole Natl Super Chim Clermont Ferrand, EA 987, Lab Chim Heterocycles & Glucides, F-63174 Aubiere, France

来源：

SYNLETT | 2007年 / 10期

关键词：

piperidines; intramolecular Michael reaction; diastereoselectivity;

D O I：

10.1055/s-2007-982547

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An intramolecular Michael-type reaction, involving beta'-amino-alpha,beta-unsaturated ketone is used to prepare 2-mono- and 2 6-disusbtituted piperidines in a diastereoselective manner. This strategy allows an easy access to 2,6-trans-piperidine, starting from either E- or Z-olefin configuration.

引用

收藏

页码：1613 / 1615

页数：3

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