FOS expression in orexin neurons following muscimol perfusion of preoptic area

被引：10

作者：

Satoh, S ^{[1
]}

Matsumura, H

Fujioka, A

Nakajima, T

Kanbayashi, T

Nishino, S

Shigeyoshi, Y

Yoneda, H

机构：

[1] Osaka Med Coll, Dept Neuropsychiat, Osaka 5698686, Japan

[2] Kinki Univ, Sch Med, Dept Anat & Neurobiol 2, Osaka 589, Japan

[3] Akita Univ, Sch Med, Dept Neuropsychiat, Akita 010, Japan

[4] Stanford Univ, Ctr Narcolepsy, Palo Alto, CA 94304 USA

来源：

NEUROREPORT | 2004年 / 15卷 / 07期

关键词：

FOS; microdialysis; muscimol; orexin (hypocretin); rat; sleep-wake activity;

D O I：

10.1097/00001756-200405190-00009

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Unilateral microdialysis-perfusion of the preoptic area with 50 muM muscimol decreased the sleep period of rats to less than 3% of the baseline value over a 90 min period before death (p=0.018 by Wilcoxon signed-rank test). These rats showed the expression of FOS in 36% of the orexin neurons located in the perifornical/lateral hypothalamic areas on the side ipsilateral to the perfusion site, but in only 3% of the orexin neurons on the side contralateral to it (p=0.018 by Wilcoxon signed-rank test). These results suggest that subpopulations of the preoptic neurons give an inhibitory tone to the activities of the orexin neurons in the perifornical/lateral hypothalamic areas.

引用

页码：1127 / 1131

页数：5

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