Nanoparticles as a novel class of autophagy activators

被引：188

作者：

Zabirnyk, Olga

Yezhelyev, Maksym

Seleverstov, Oleksandr

机构：

[1] Univ Leipzig, Ctr Biotechnol & Biomed, BBZ, D-04103 Leipzig, Germany

[2] Univ Leipzig, Inst Anat, D-04103 Leipzig, Germany

[3] Emory Univ, Winship Canc Inst, Atlanta, GA 30322 USA

来源：

AUTOPHAGY | 2007年 / 3卷 / 03期

关键词：

nanoparticles; physical properties; environment; targeted therapy; autophagy;

D O I：

10.4161/auto.3916

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Nano-sized objects exist as engineered tools as well as natural or anthropogenic environmental factors. Recent progress in the field of nanotechnology allows for a deeper understanding of their impact on organisms. Recently, we showed that the size-dependent cell interaction with quantum dots is autophagy-mediated. The potential role of other endo- and exogenous nanoparticles in terms of autophagy is discussed here. Their physical properties should be taken into consideration while constructing delivery systems. Furthermore, we propose several models of targeted nanoparticles delivery. Autophagy can be considered as an additional mechanism providing intracellular selectivity for introduced nanoparticles.

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收藏

页码：278 / 281

页数：4

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