Pre-B and pre-T-cell receptors: conservation of strategies in regulating early lymphocyte development

被引：39

作者：

Muljo, SA

Schlissel, MS

机构：

[1] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

[2] Johns Hopkins Univ, Sch Med, Grad Program Immunol, Baltimore, MD USA

来源：

IMMUNOLOGICAL REVIEWS | 2000年 / 175卷

关键词：

D O I：

10.1034/j.1600-065X.2000.017509.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Early lymphocyte development is characterized by the regulated activity of the V(D)J recombinase and the positive and negative selection of cells based on the structure of their assembled antigen receptor genes. Developing B and T cells use remarkably similar signaling complexes, the pre-B-cell receptor (pre-BCR) and the pre-T-cell receptor (pre-TCR) respectively, to monitor the progress of antigen receptor gene assembly This review will compare and contrast the regulation and activities of the pre-BCR and prc-TCR signaling complexes, in addition, we will consider a number of critical but as yet unanswered questions prompted by such an analysis.

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页码：80 / 93

页数：14

相关论文

共 129 条

[71]

MCMAHON SB, 1995, MOL CELL BIOL, V15, P1086

[72] ACTIVATION OF THE P21(RAS) PATHWAY COUPLES ANTIGEN RECEPTOR STIMULATION TO INDUCTION OF THE PRIMARY RESPONSE GENE EGR-1 IN B-LYMPHOCYTES [J].

MCMAHON, SB ;

MONROE, JG .

JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 181 (01) :417-422

[73] POSITIVE AND NEGATIVE SELECTION EVENTS DURING B-LYMPHOPOIESIS [J].

MELCHERS, F ;

ROLINK, A ;

GRAWUNDER, U ;

WINKLER, TH ;

KARASUYAMA, H ;

GHIA, P ;

ANDERSSON, J .

CURRENT OPINION IN IMMUNOLOGY, 1995, 7 (02) :214-227

[74] Fit for life in the immune system? Surrogate L chain tests H chains that test L chains [J].

Melchers, F .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (06) :2571-2573

[75] Two distinct steps during thymocyte maturation from CD4(-)CD8(-)to CD4(+)CD8(+) distinguished in the early growth response (Egr)-1 transgenic mice with a recombinase-activating gene-deficient background [J].

Miyazaki, T .

JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 186 (06) :877-885

[76] AN ACTIVATED LCK TRANSGENE PROMOTES THYMOCYTE DEVELOPMENT IN RAG-1 MUTANT MICE [J].

MOMBAERTS, P ;

ANDERSON, SJ ;

PERLMUTTER, RM ;

MAK, TW ;

TONEGAWA, S .

IMMUNITY, 1994, 1 (04) :261-267

[77]

Morrow TA, 1999, MOL CELL BIOL, V19, P5608

[78] CONSTITUTIVE ACTIVATION OF SRC FAMILY KINASES IN MOUSE EMBRYOS THAT LACK CSK [J].

NADA, S ;

YAGI, T ;

TAKEDA, H ;

TOKUNAGA, T ;

NAKAGAWA, H ;

IKAWA, Y ;

OKADA, M ;

AIZAWA, S .

CELL, 1993, 73 (06) :1125-1135

[79] The Ig alpha/Ig beta heterodimer on mu-negative ProB cells is competent for transducing signals to induce early B cell differentiation [J].

Nagata, K ;

Nakamura, T ;

Kitamura, F ;

Kuramochi, S ;

Taki, S ;

Campbell, KS ;

Karasuyama, H .

IMMUNITY, 1997, 7 (04) :559-570

[80] Rearrangement and expression of immunoglobulin light chain genes can precede heavy chain expression during normal B cell development in mice [J].

Novobrantseva, TI ;

Martin, VM ;

Pelanda, R ;

Müller, W ;

Rajewsky, K ;

Ehlich, A .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (01) :75-87

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