New C-N and C-C bond forming reactions catalyzed by titanium complexes

被引：294

作者：

Odom, AL ^{[1
]}

机构：

[1] Michigan State Univ, Dept Chem, E Lansing, MI 48911 USA

来源：

DALTON TRANSACTIONS | 2005年 / 02期

关键词：

D O I：

10.1039/b415701j

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Titanium(IV) complexes with two basic dimethylamido ligands can be efficient catalysts for alkyne hydroamination by primary amines. Readily prepared pyrrolyl ligands have proven to be especially useful in generating active catalysts for hydroamination and hydrohydrazination. From these reactions, new methodologies for the synthesis of imines, hydrazones, alpha,beta-unsaturated imines, pyridines, indoles, and pyrroles have developed. In addition, a new reaction that is mechanistically related to hydroamination, alkyne iminoamination, has been discovered. Iminoamination, which is a multicomponent coupling between an amine, alkyne, and isonitrile, provides unsymmetrical alpha,beta-unsaturated beta-iminoamines in a single, titanium-catalyzed step.

引用

页码：225 / 233

页数：9

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