Chirally templated boronic acid Mannich reaction in the synthesis of optically active α-amino acids

被引：37

作者：

Currie, GS

Drew, MGB

Harwood, LM

Hughes, DJ

Luke, RWA

Vickers, RJ

机构：

[1] Univ Reading, Dept Chem, Reading RG6 6AD, Berks, England

[2] Univ Oxford, Dyson Perrins Lab, Oxford OX1 3QY, England

[3] AstroZeneca Agrochem, Jealotts Hill Res Stn, Bracknell RG42 6ET, Berks, England

[4] AstraZeneca, Macclesfield SK10 4TG, Cheshire, England

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 2000年 / 17期

关键词：

D O I：

10.1039/b003067h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Adducts from diastereoselective Mannich-type reactions of aldehydes, 2-furylboronic acid and the chiral amine template (S)-5-phenylmorpholin-2-one, have been used in the synthesis of a series of enantiomerically pure D-alpha-amino acids.

引用

页码：2982 / 2990

页数：9

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