Synthesis of some hydroxynaphthazarins and their cardioprotective effects under ischemia-reperfusion in vivo

被引：79

作者：

Anufriev, VP ^{[1
]}

Novikov, VL

Maximov, OB

Elyakov, GB

Levitsky, DO

Lebedev, AV

Sadretdinov, SM

Shvilkin, AV

Afonskaya, NI

Ruda, MY

Cherpachenko, NM

机构：

[1] Russian Acad Sci, Pacific Inst Bioorgan Chem, Vladivostok 690022, Russia

[2] Inst Expt Cardiol, Cardiol Res Ctr, Moscow 121552, Russia

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(98)00075-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of hydroxynaphthazarins has been synthesized. Some of them were found in in vivo experiments to be protectors of myocardium under ischemia-reperfusion and to reduce the infarction zone by 50% without any adverse effect. All compounds exhibit a moderate or small toxicity and are active in low doses. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：587 / 592

页数：6

共 21 条

[1] FLUORIDE SALTS-ALCOHOLS-ALUMINA AS REAGENTS FOR NUCLEOPHILIC-SUBSTITUTION OF CHLORINE ATOMS FOR ALKOXY GROUPS IN 2,3-DICHLOROSUBSTITUTED JUGLONES, NAPHTHAZARINES, AND QUINIZARINES [J].

ANUFRIEV, VP ;

NOVIKOV, VL .

TETRAHEDRON LETTERS, 1995, 36 (14) :2515-2518

[2]

BOGUSLAVSKAYA LV, 1985, IAN SSSR KH, V7, P1471

[3]

BOGUSLAVSKAYA LV, 1988, IAN SSSR KH, P283

[4] MYOCARDIAL REPERFUSION, LIMITATION OF INFARCT SIZE, REDUCTION OF LEFT-VENTRICULAR DYSFUNCTION, AND IMPROVED SURVIVAL - SHOULD THE PARADIGM BE EXPANDED [J].

BRAUNWALD, E .

CIRCULATION, 1989, 79 (02) :441-444

[5] MYOCARDIAL REPERFUSION - A DOUBLE-EDGED SWORD [J].

BRAUNWALD, E ;

KLONER, RA .

JOURNAL OF CLINICAL INVESTIGATION, 1985, 76 (05) :1713-1719

[6] MYOCARDIAL-METABOLISM IN ISCHEMIC HEART-DISEASE - BASIC PRINCIPLES AND APPLICATION TO IMAGING BY POSITRON EMISSION TOMOGRAPHY [J].

CAMICI, P ;

FERRANNINI, E ;

OPIE, LH .

PROGRESS IN CARDIOVASCULAR DISEASES, 1989, 32 (03) :217-238

[7]

GODFREY M, 1974, J CHEM SOC P1, V11, P1353

[8] FRIEDEL-CRAFTS CONDENSATIONS WITH MALEIC ANHYDRIDES .3. SYNTHESIS OF POLYHYDROXYLATED NAPHTHOQUINONES [J].

HUOT, R ;

BRASSARD, P .

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1974, 52 (05) :838-842

[9] THERAPEUTIC POTENTIAL OF VITAMIN-E AGAINST MYOCARDIAL ISCHEMIC-REPERFUSION INJURY [J].

JANERO, DR .

FREE RADICAL BIOLOGY AND MEDICINE, 1991, 10 (05) :315-324

[10] FREE-RADICALS AND THE HEART [J].

KAUL, N ;

SIVESKIILISKOVIC, N ;

HILL, M ;

SLEZAK, J ;

SINGAL, PK .

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 1993, 30 (02) :55-67

← 1 2 3 →