αvβ integrins play an essential role in BMP-2 induction of osteoblast differentiation

被引：116

作者：

Lai, CF ^{[1
]}

Cheng, SL ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Div Bone & Mineral Dis, Dept Internal Med, St Louis, MO 63110 USA

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2005年 / 20卷 / 02期

关键词：

integrins; bone morphogenetic protein-2; osteoblasts; proliferation; differentiation;

D O I：

10.1359/JBMR.041013

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Both integrins and BMP-2 exert similar effects on osteoblasts. We examined the relationship between the alphav-containing integrins (alphavbeta) and BMP-2 in osteoblast function. BMP-2 stimulates alphavbeta expression. BMP-2 receptors co-localize/overlap with alphavbeta integrins, and the intact function of alphavbeta is essential in BMP-2 activity.

引用

页码：330 / 340

页数：11

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