Evaluation of the effects of several zoanthamine-type alkaloids on the aggregation of human platelets

被引：63

作者：

Villar, RM

Gil-Longo, J

Daranas, AH

Souto, ML

Fernández, JJ

Peixinho, S

Barral, MA

Santafé, G

Rodríguez, J

Jiménez, C

机构：

[1] Univ A Coruna, Fac Ciencias, Dept Quim Fundamental, La Coruna 15071, Spain

[2] Univ Santiago de Compostela, Fac Farm, Dept Farmacol, Santiago De Compostela 15782, Spain

[3] Univ La Laguna, Inst Bioorgan Antonio Gonzalez, San Cristobal la Laguna 38206, Spain

[4] Univ Fed Bahia, Inst Biol, Dept Zool, BR-4071290 Salvador, BA, Brazil

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2003年 / 11卷 / 10期

关键词：

D O I：

10.1016/S0968-0896(03)00107-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ten zoanthamine-type alkaloids from two marine zoanthids belonging to the Zoanthus genus (Zoanthus nymphaeus and Zoanthus sp.) along with one semisynthetic derivative were evaluated for their antiplatelet activities on human platelet aggregation induced by several stimulating agents. 11-Hydroxyzoanthamine (11) and a synthetic derivative of norzoanthamine (16) showed strong inhibition against thrombin-, collagen- and arachidonic acid-induced aggregation, zoanthenol (15) displayed a selective inhibitory activity induced by collagen, while zoanthaminone (10) behaved as a potent aggregant agent. These evaluations allowed us to deduce several structure-activity relationships and suggest some mechanisms of action for this type of compounds. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：2301 / 2306

页数：6

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