Molecular mechanisms of antibiotic resistance

被引：3221

作者：

Blair, Jessica M. A. ^{[1
]}

Webber, Mark A. ^{[1
]}

Baylay, Alison J. ^{[1
]}

Ogbolu, David O. ^{[1
]}

Piddock, Laura J. V. ^{[1
]}

机构：

[1] Univ Birmingham, Antimicrobials Res Grp, Sch Immun & Infect, Inst Microbiol & Infect, Birmingham B15 2TT, W Midlands, England

来源：

NATURE REVIEWS MICROBIOLOGY | 2015年 / 13卷 / 01期

基金：

英国医学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

SPECTRUM BETA-LACTAMASES; CARBAPENEMASE-PRODUCING ENTEROBACTERIACEAE; CASSETTE CHROMOSOME MEC; MULTIDRUG EFFLUX PUMP; IN-VITRO ACTIVITY; KLEBSIELLA-PNEUMONIAE; ESCHERICHIA-COLI; CRYSTAL-STRUCTURE; PSEUDOMONAS-AERUGINOSA; STAPHYLOCOCCUS-AUREUS;

D O I：

10.1038/nrmicro3380

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学];

摘要：

Antibiotic-resistant bacteria that are difficult or impossible to treat are becoming increasingly common and are causing a global health crisis. Antibiotic resistance is encoded by several genes, many of which can transfer between bacteria. New resistance mechanisms are constantly being described, and new genes and vectors of transmission are identified on a regular basis. This article reviews recent advances in our understanding of the mechanisms by which bacteria are either intrinsically resistant or acquire resistance to antibiotics, including the prevention of access to drug targets, changes in the structure and protection of antibiotic targets and the direct modification or inactivation of antibiotics.

引用

页码：42 / 51

页数：10

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