Muscle/heart isoform of mitochondrial adenine nucleotide translocase (ANT1) is transiently expressed during perinatal development in rat liver

被引：7

作者：

Grado, A ^{[1
]}

Manchado, C ^{[1
]}

Iglesias, R ^{[1
]}

Giralt, M ^{[1
]}

Villarroya, F ^{[1
]}

Mampel, T ^{[1
]}

Viñas, O ^{[1
]}

机构：

[1] Univ Barcelona, Fac Biol, Dept Bioquim & Biol Mol, E-08028 Barcelona, Spain

来源：

FEBS LETTERS | 1998年 / 421卷 / 03期

关键词：

adenine nucleotide translocator; isoform; perinatal liver; respiration;

D O I：

10.1016/S0014-5793(97)01563-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A postnatal increase in the content of mitochondrial ANT in rat liver which is related to the maturation of mitochondrial function has previously been reported [Schonfeld et al., Biochim. Biophys Acta 1144 (1993) 353-358]. In order to define the contribution of the ANT isoforms to this postnatal increase we have studied the expression of ANT1 and ANT2 isoforms in the liver during this period, The results shea that in contrast to adult liver, perinatal liver expressed the ANT1 isoform at the mRNA and protein level, and that during this period the expression of ANT1 increased to a similar extent as total ANT content, It is concluded that the postnatal increase in ANT is mainly due to the ANT1 isoform and therefore, a role for the ANT1 isoform in the postnatal maturation of mitochondrial respiration in rat liver is suggested. (C) 1998 Federation of European Biochemical Societies.

引用

页码：213 / 216

页数：4

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