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WNT signalling and haematopoiesis: A WNT-WNT situation

被引：253
作者：
Staal, FJT
Clevers, HC
机构：
[1] Erasmus Med Ctr, Dept Immunol, NL-3015 GE Rotterdam, Netherlands
[2] Hubrecht Lab Dev Biol, Utrecht, Netherlands
来源：
NATURE REVIEWS IMMUNOLOGY | 2005年 / 5卷 / 01期
关键词：
D O I：
10.1038/nri1529
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The evolutionarily conserved WNT-signalling pathway has pivotal roles during the development of many organ systems, and dysregulated WNT signalling is a key factor in the initiation of various tumours. Recent studies have implicated a role for WNT signal transduction at several stages of lymphocyte development and in the self-renewal of haematopoietic stem cells. Here, we outline new insights into the WNT-signalling pathway, review its role in the self-renewal of haematopoietic stem cells and in the development of T and B cells, and discuss controversies and future developments with regard to WNT signalling in the thymus.
引用
收藏
页码：21 / 30
页数：10
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