WNT signalling and haematopoiesis: A WNT-WNT situation

被引：253

作者：

Staal, FJT

Clevers, HC

机构：

[1] Erasmus Med Ctr, Dept Immunol, NL-3015 GE Rotterdam, Netherlands

[2] Hubrecht Lab Dev Biol, Utrecht, Netherlands

来源：

NATURE REVIEWS IMMUNOLOGY | 2005年 / 5卷 / 01期

关键词：

D O I：

10.1038/nri1529

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The evolutionarily conserved WNT-signalling pathway has pivotal roles during the development of many organ systems, and dysregulated WNT signalling is a key factor in the initiation of various tumours. Recent studies have implicated a role for WNT signal transduction at several stages of lymphocyte development and in the self-renewal of haematopoietic stem cells. Here, we outline new insights into the WNT-signalling pathway, review its role in the self-renewal of haematopoietic stem cells and in the development of T and B cells, and discuss controversies and future developments with regard to WNT signalling in the thymus.

引用

页码：21 / 30

页数：10

共 71 条

[51] Chibby, a nuclear β-catenin-associated antagonist of the Wnt/Wingless pathway
Takemaru, KI
Yamaguchi, S
Lee, YS
Zhang, Y
Carthew, RW
Moon, RT
[J]. NATURE, 2003, 422 (6934) : 905 - 909
[52] LDL-receptor-related proteins in Wnt signal transduction
Tamai, K
Semenov, M
Kato, Y
Spokony, R
Liu, CM
Katsuyama, Y
Hess, F
Saint-Jeannet, JP
He, X
[J]. NATURE, 2000, 407 (6803) : 530 - 535
[53] A complex of armadillo, legless, and pygopus coactivates dTCF to activate wingless target genes
Thompson, BJ
[J]. CURRENT BIOLOGY, 2004, 14 (06) : 458 - 466
[54] The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma
Tian, E
Zhan, FH
Walker, R
Rasmussen, E
Ma, YP
Barlogie, B
Shaughnessy, JD
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2003, 349 (26) : 2483 - 2494
[55] Pygopus residues required for its binding to legless are critical for transcription and development
Townsley, FM
Thompson, B
Bienz, M
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (07) : 5177 - 5183
[56] Pygopus and Legless target Armadillo/β-catenin to the nucleus to enable its transcriptional co-activator function
Townsley, FM
Cliffe, A
Bienz, M
[J]. NATURE CELL BIOLOGY, 2004, 6 (07) : 626 - 633
[57] LEF-1, A GENE ENCODING A LYMPHOID-SPECIFIC WITH PROTEIN, AN HMG DOMAIN, REGULATES T-CELL RECEPTOR-ALPHA ENHANCER FUNCTION
TRAVIS, A
AMSTERDAM, A
BELANGER, C
GROSSCHEDL, R
[J]. GENES & DEVELOPMENT, 1991, 5 (05) : 880 - 894
[58] The β-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells
van de Wetering, M
Sancho, E
Verweij, C
de Lau, W
Oving, I
Hurlstone, A
van der Horn, K
Batlle, E
Coudreuse, D
Haramis, AP
Tion-Pon-Fong, M
Moerer, P
van den Born, M
Soete, G
Pals, S
Eilers, M
Medema, R
Clevers, H
[J]. CELL, 2002, 111 (02) : 241 - 250
[59] Role of members of the Wnt gene family in human hematopoiesis
Van den Berg, DJ
Sharma, AK
Bruno, E
Hoffman, R
[J]. BLOOD, 1998, 92 (09) : 3189 - 3202
[60] You Wnt some, you lose some: oncogenes in the Wnt signaling pathway
van Es, JH
Barker, N
Clevers, H
[J]. CURRENT OPINION IN GENETICS & DEVELOPMENT, 2003, 13 (01) : 28 - 33

← 1 2 3 4 5 6 7 8 →