h1-2-pyrone metal carbonyl complexes as CO-releasing molecules (CO-RMs):: A delicate balance between stability and CO liberation

被引：68

作者：

Fairlamb, Ian J. S. ^{[1
]}

Lynam, Jason M.

Moulton, Benjamin E.

Taylor, Ian E.

Duhme-Klair, Anne K.

Sawle, Philip

Motterlini, Roberto

机构：

[1] Univ York, Dept Chem, York YO10 5DD, N Yorkshire, England

[2] Northwick Pk Inst Med Res, Dept Surg Res, Vasc Biol Unit, Harrow HA1 3UJ, Middx, England

来源：

DALTON TRANSACTIONS | 2007年 / 33期

关键词：

D O I：

10.1039/b707377a

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

An evaluation of the CO releasing ability of iron(II) and molybdenum( II) complexes has facilitated the discovery of the most rapid CO releaser, namely [Mo( CO) 3(eta(5)-C5H5)(eta(1)-{O} C{= O}-O-CMe=CH-COMe=CBr)]BF4 (CORM-F10), reported to date. The rate of CO release is related to the overall solution phase stability of the transition metal carbonyl complex. The cytotoxity and vasodilatory properties of CORM-F10 have been determined.

引用

页码：3603 / 3605

页数：3

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