Biodemographic trajectories of longevity

被引:677
作者
Vaupel, JW
Carey, JR
Christensen, K
Johnson, TE
Yashin, AI
Holm, NV
Iachine, IA
Kannisto, V
Khazaeli, AA
Liedo, P
Longo, VD
Zeng, Y
Manton, KG
Curtsinger, JW
机构
[1] Max Planck Inst Demog Res, D-18057 Rostock, Germany
[2] Odense Univ, Sch Med, DK-5000 Odense C, Denmark
[3] Duke Univ, Ctr Demog Studies, Durham, NC 27706 USA
[4] Univ So Calif, Ethel Percy Andrus Gerontol Ctr, Los Angeles, CA 90089 USA
[5] Univ Calif Davis, Dept Entomol, Davis, CA 95616 USA
[6] Univ Colorado, Inst Behav Genet, Boulder, CO 80309 USA
[7] Univ Minnesota, Dept Ecol Evolut & Behav, St Paul, MN 55108 USA
[8] Colegio Frontera Sur, Tapachula 30700, Mexico
[9] Peking Univ, Inst Populat Res, Beijing 100871, Peoples R China
关键词
D O I
10.1126/science.280.5365.855
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Old-age survival has increased substantially since 1950. Death rates decelerate with age for insects, worms, and yeast, as well as humans. This evidence of extended postreproductive survival is puzzling. Three biodemographic insights-concerning the correlation of death rates across age, individual differences in survival chances, and induced alterations in age patterns of fertility and mortality-offer clues and suggest research on the failure of complicated systems, on new demographic equations for evolutionary theory, and on fertility-longevity interactions. Nongenetic changes account for increases in human life-spans to date. Explication of these causes and the genetic license for extended survival, as well as discovery of genes and other survival attributes affecting longevity, will lead to even longer lives.
引用
收藏
页码:855 / 860
页数:6
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