A new sesquiterpene ester from Celastrus orbiculatus reversing multidrug resistance in cancer gels

被引：59

作者：

Kim, SE

Kim, YH

Lee, JJ

Kim, YC

机构：

[1] Korea Res Inst Biosci & Biotechnol, Nat Prod & Biosynthesis Res Unit, Taejon 305600, South Korea

[2] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea

来源：

JOURNAL OF NATURAL PRODUCTS | 1998年 / 61卷 / 01期

关键词：

D O I：

10.1021/np9702392

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

In a search for revertants of multidrug-resistance in cancer cells, a novel (1) and two known (2, 3) sesquiterpene esters were isolated from the root of Celastrus orbiculatus. The structure of 1 was elucidated as 1 beta,2 beta-diacetoxy-6 alpha,9 alpha-bis(benzoyloxy)dihydro-beta-agarofuran. Compounds 1-3 partially or completely reversed resistance to adriamycin, vinblastine, and paclitaxel of multidrug-resistant KB-V1 and MCF7/ADR cells.

引用

页码：108 / 111

页数：4