From plankton to pathogen recognition

被引：17

作者：

Modlin, RL ^{[1
]}

Cheng, GH

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Div Dermatol, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Microbiol Mol Genet & Immunol, Los Angeles, CA 90095 USA

来源：

NATURE MEDICINE | 2004年 / 10卷 / 11期

关键词：

D O I：

10.1038/nm1104-1173

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two studies in the mid-1990s cracked a mystery of innate immunity-how foreign invaders are recognized. One study found that signaling through Toll-like receptor 4 activated the immune response. Another identified the signal: lipopolysaccharide (LPS), a cell envelope component of Gram-negative bacteria. The discoveries brought full circle observations that began with starfish in the 1880s.

引用

页码：1173 / 1174

页数：2

共 25 条

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