Convenient methods for the synthesis of ferrocene-carbohydrate conjugates

被引：128

作者：

Casas-Solvas, JM

Vargas-Berenguel, A ^{[1
]}

Capitán-Vallvey, LF

Santoyo-González, F

机构：

[1] Univ Almeria, Area Quim Organ, Almeria 04120, Spain

[2] Univ Granada, Dept Quim Analit, Fac Ciencias, E-18071 Granada, Spain

[3] Univ Granada, Inst Biotecnol, Fac Ciencias, E-18071 Granada, Spain

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 21期

关键词：

D O I：

10.1021/ol048665j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report two methods for the attachment of mono- and disaccharides to one or both of the cyclopentadienyl rings in ferrocene. The first strategy involves the reaction in acidic media of thioglycosides with ferrocenemethanol or 1,1'-ferrocenedimethanol. The second method consists of the regiospecific catalytic cycloaddition of propargyl glycoside and azidomethyl and bis(azidomethyl)ferrocene leading to the 1,2,3-triazole derivatives. The inverse strategy was also explored. The electrochemical behavior of the synthesized ferrocene-containing glycoconjugates was investigated.

引用

页码：3687 / 3690

页数：4

共 49 条

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