Labeling of organic biomolecules with ethynylferrocene

被引:45
作者
Coutouli-Argyropoulou, E [1 ]
Tsitabani, M
Petrantonakis, G
Terzis, A
Raptopoulou, C
机构
[1] Aristotle Univ Thessaloniki, Dept Chem, Thessaloniki 54124, Greece
[2] NCSR Demokritos, Inst Mat Sci, Aghia Paraskevi 15310, Attiki, Greece
关键词
D O I
10.1039/b300191a
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The Sonogashira coupling reaction of ethynylferrocene with adenine, uracil, tyrosine and steroid derivatives was studied; with the exception of tyrosine it was proved to be a good route for the attachment of ferrocene to these representative biomolecules. In addition the transformation of alkynyl uracil to furanopyrimidone derivatives was investigated and the formation of the furanopyrimidone ring was confirmed by an X-ray crystallographic analysis carried out on product 16.
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页码:1382 / 1388
页数:7
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