Stereospecific alkyne reduction:: Novel activity of old yellow enzymes

被引：50

作者：

Muller, Andre

Sturmer, Rainer

Hauer, Bernhard

Rosche, Bettina ^{[1
]}

机构：

[1] Univ New S Wales, Sch Biotechnol & Biomol Sci, Sydney, NSW 2031, Australia

[2] BASF AG, Fine Chem & Biocatalysis Res, D-67056 Ludwigshafen, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 18期

关键词：

alkynes; biotransformation; enzyme catalysis; green chemistry; reduction;

D O I：

10.1002/anie.200605179

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Old enzyme, new trick: An environmentally sustainable alternative for the regio-and stereoselective reduction of the alkyne bond is the biotransformation by "Old Yellow Enzyme" (OYE). This "old" enzyme, first isolated in 1932, catalyzes the trans-selective hydrogenation of the carbon-carbon triple bond under mild conditions. (Chemical Equation Presented). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

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收藏

页码：3316 / 3318

页数：3

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