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Temsirolimus
被引:32
作者
:
Rini, Brian
论文数:
0
引用数:
0
h-index:
0
机构:
Cleveland Clin, Taussig Canc Ctr, Dept Solid Tumor Oncol & Urol, Cleveland, OH 44195 USA
Rini, Brian
Kar, Santwana
论文数:
0
引用数:
0
h-index:
0
机构:
Cleveland Clin, Taussig Canc Ctr, Dept Solid Tumor Oncol & Urol, Cleveland, OH 44195 USA
Kar, Santwana
Kirkpatrick, Peter
论文数:
0
引用数:
0
h-index:
0
机构:
Cleveland Clin, Taussig Canc Ctr, Dept Solid Tumor Oncol & Urol, Cleveland, OH 44195 USA
Kirkpatrick, Peter
机构
:
[1]
Cleveland Clin, Taussig Canc Ctr, Dept Solid Tumor Oncol & Urol, Cleveland, OH 44195 USA
[2]
IMS Hlth, London NW1 6JB, England
来源
:
NATURE REVIEWS DRUG DISCOVERY
|
2007年
/ 6卷
/ 08期
关键词
:
D O I
:
10.1038/nrd2382
中图分类号
:
Q81 [生物工程学(生物技术)];
Q93 [微生物学];
学科分类号
:
071005 ;
0836 ;
090102 ;
100705 ;
摘要
:
Temsirolimus (Torisel; Wyeth) is an inhibitor of the kinase mTOR (mammalian target of rapamycin). It was approved by the US FDA for the treatment of advanced renal cell carcinoma in May 2007.
引用
收藏
页码:599 / 600
页数:2
相关论文
共 14 条
[11]
Safety and pharmacokinetics of escalated doses of weekly intravenous infusion of CCI-779, a novel mTOR inhibitor, in patients with cancer
[J].
Raymond, E
论文数:
0
引用数:
0
h-index:
0
机构:
Inst Gustave Roussy, Dept Med, Villejuif, France
Raymond, E
;
Alexandre, J
论文数:
0
引用数:
0
h-index:
0
机构:
Inst Gustave Roussy, Dept Med, Villejuif, France
Alexandre, J
;
Faivre, S
论文数:
0
引用数:
0
h-index:
0
机构:
Inst Gustave Roussy, Dept Med, Villejuif, France
Faivre, S
;
Vera, K
论文数:
0
引用数:
0
h-index:
0
机构:
Inst Gustave Roussy, Dept Med, Villejuif, France
Vera, K
;
Materman, E
论文数:
0
引用数:
0
h-index:
0
机构:
Inst Gustave Roussy, Dept Med, Villejuif, France
Materman, E
;
Boni, J
论文数:
0
引用数:
0
h-index:
0
机构:
Inst Gustave Roussy, Dept Med, Villejuif, France
Boni, J
;
Leister, C
论文数:
0
引用数:
0
h-index:
0
机构:
Inst Gustave Roussy, Dept Med, Villejuif, France
Leister, C
;
Korth-Bradley, J
论文数:
0
引用数:
0
h-index:
0
机构:
Inst Gustave Roussy, Dept Med, Villejuif, France
Korth-Bradley, J
;
Hanauske, A
论文数:
0
引用数:
0
h-index:
0
机构:
Inst Gustave Roussy, Dept Med, Villejuif, France
Hanauske, A
;
Armand, JP
论文数:
0
引用数:
0
h-index:
0
机构:
Inst Gustave Roussy, Dept Med, Villejuif, France
Armand, JP
.
JOURNAL OF CLINICAL ONCOLOGY,
2004,
22
(12)
:2336
-2347
[12]
Skotnicki JS, 2001, CLIN CANCER RES, V7, p3749S
[13]
Discovery and development of sorafenib: a multikinase inhibitor for treating cancer
[J].
Wilhelm, Scott
论文数:
0
引用数:
0
h-index:
0
机构:
Bayer Pharmaceut Corp, Dept Canc Res, West Haven, CT 06516 USA
Bayer Pharmaceut Corp, Dept Canc Res, West Haven, CT 06516 USA
Wilhelm, Scott
;
Carter, Christopher
论文数:
0
引用数:
0
h-index:
0
机构:
Bayer Pharmaceut Corp, Dept Canc Res, West Haven, CT 06516 USA
Bayer Pharmaceut Corp, Dept Canc Res, West Haven, CT 06516 USA
Carter, Christopher
;
Lynch, Mark
论文数:
0
引用数:
0
h-index:
0
机构:
Bayer Pharmaceut Corp, Dept Canc Res, West Haven, CT 06516 USA
Bayer Pharmaceut Corp, Dept Canc Res, West Haven, CT 06516 USA
Lynch, Mark
;
Lowinger, Timothy
论文数:
0
引用数:
0
h-index:
0
机构:
Bayer Pharmaceut Corp, Dept Canc Res, West Haven, CT 06516 USA
Bayer Pharmaceut Corp, Dept Canc Res, West Haven, CT 06516 USA
Lowinger, Timothy
;
Dumas, Jacques
论文数:
0
引用数:
0
h-index:
0
机构:
Bayer Pharmaceut Corp, Dept Canc Res, West Haven, CT 06516 USA
Bayer Pharmaceut Corp, Dept Canc Res, West Haven, CT 06516 USA
Dumas, Jacques
;
Smith, Roger A.
论文数:
0
引用数:
0
h-index:
0
机构:
Bayer Pharmaceut Corp, Dept Canc Res, West Haven, CT 06516 USA
Bayer Pharmaceut Corp, Dept Canc Res, West Haven, CT 06516 USA
Smith, Roger A.
;
Schwartz, Brian
论文数:
0
引用数:
0
h-index:
0
机构:
Bayer Pharmaceut Corp, Dept Canc Res, West Haven, CT 06516 USA
Bayer Pharmaceut Corp, Dept Canc Res, West Haven, CT 06516 USA
Schwartz, Brian
;
Simantov, Ronit
论文数:
0
引用数:
0
h-index:
0
机构:
Bayer Pharmaceut Corp, Dept Canc Res, West Haven, CT 06516 USA
Bayer Pharmaceut Corp, Dept Canc Res, West Haven, CT 06516 USA
Simantov, Ronit
;
Kelley, Susan
论文数:
0
引用数:
0
h-index:
0
机构:
Bayer Pharmaceut Corp, Dept Canc Res, West Haven, CT 06516 USA
Bayer Pharmaceut Corp, Dept Canc Res, West Haven, CT 06516 USA
Kelley, Susan
.
NATURE REVIEWS DRUG DISCOVERY,
2006,
5
(10)
:835
-844
[14]
A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer
[J].
Yang, JC
论文数:
0
引用数:
0
h-index:
0
机构:
NCI, Surg Branch, NIH, Bethesda, MD 20892 USA
Yang, JC
;
Haworth, L
论文数:
0
引用数:
0
h-index:
0
机构:
NCI, Surg Branch, NIH, Bethesda, MD 20892 USA
Haworth, L
;
Sherry, RM
论文数:
0
引用数:
0
h-index:
0
机构:
NCI, Surg Branch, NIH, Bethesda, MD 20892 USA
Sherry, RM
;
Hwu, P
论文数:
0
引用数:
0
h-index:
0
机构:
NCI, Surg Branch, NIH, Bethesda, MD 20892 USA
Hwu, P
;
Schwartzentruber, DJ
论文数:
0
引用数:
0
h-index:
0
机构:
NCI, Surg Branch, NIH, Bethesda, MD 20892 USA
Schwartzentruber, DJ
;
Topalian, SL
论文数:
0
引用数:
0
h-index:
0
机构:
NCI, Surg Branch, NIH, Bethesda, MD 20892 USA
Topalian, SL
;
Steinberg, SM
论文数:
0
引用数:
0
h-index:
0
机构:
NCI, Surg Branch, NIH, Bethesda, MD 20892 USA
Steinberg, SM
;
Chen, HX
论文数:
0
引用数:
0
h-index:
0
机构:
NCI, Surg Branch, NIH, Bethesda, MD 20892 USA
Chen, HX
;
Rosenberg, SA
论文数:
0
引用数:
0
h-index:
0
机构:
NCI, Surg Branch, NIH, Bethesda, MD 20892 USA
Rosenberg, SA
.
NEW ENGLAND JOURNAL OF MEDICINE,
2003,
349
(05)
:427
-434
←
1
2
→
共 14 条
[11]
Safety and pharmacokinetics of escalated doses of weekly intravenous infusion of CCI-779, a novel mTOR inhibitor, in patients with cancer
[J].
Raymond, E
论文数:
0
引用数:
0
h-index:
0
机构:
Inst Gustave Roussy, Dept Med, Villejuif, France
Raymond, E
;
Alexandre, J
论文数:
0
引用数:
0
h-index:
0
机构:
Inst Gustave Roussy, Dept Med, Villejuif, France
Alexandre, J
;
Faivre, S
论文数:
0
引用数:
0
h-index:
0
机构:
Inst Gustave Roussy, Dept Med, Villejuif, France
Faivre, S
;
Vera, K
论文数:
0
引用数:
0
h-index:
0
机构:
Inst Gustave Roussy, Dept Med, Villejuif, France
Vera, K
;
Materman, E
论文数:
0
引用数:
0
h-index:
0
机构:
Inst Gustave Roussy, Dept Med, Villejuif, France
Materman, E
;
Boni, J
论文数:
0
引用数:
0
h-index:
0
机构:
Inst Gustave Roussy, Dept Med, Villejuif, France
Boni, J
;
Leister, C
论文数:
0
引用数:
0
h-index:
0
机构:
Inst Gustave Roussy, Dept Med, Villejuif, France
Leister, C
;
Korth-Bradley, J
论文数:
0
引用数:
0
h-index:
0
机构:
Inst Gustave Roussy, Dept Med, Villejuif, France
Korth-Bradley, J
;
Hanauske, A
论文数:
0
引用数:
0
h-index:
0
机构:
Inst Gustave Roussy, Dept Med, Villejuif, France
Hanauske, A
;
Armand, JP
论文数:
0
引用数:
0
h-index:
0
机构:
Inst Gustave Roussy, Dept Med, Villejuif, France
Armand, JP
.
JOURNAL OF CLINICAL ONCOLOGY,
2004,
22
(12)
:2336
-2347
[12]
Skotnicki JS, 2001, CLIN CANCER RES, V7, p3749S
[13]
Discovery and development of sorafenib: a multikinase inhibitor for treating cancer
[J].
Wilhelm, Scott
论文数:
0
引用数:
0
h-index:
0
机构:
Bayer Pharmaceut Corp, Dept Canc Res, West Haven, CT 06516 USA
Bayer Pharmaceut Corp, Dept Canc Res, West Haven, CT 06516 USA
Wilhelm, Scott
;
Carter, Christopher
论文数:
0
引用数:
0
h-index:
0
机构:
Bayer Pharmaceut Corp, Dept Canc Res, West Haven, CT 06516 USA
Bayer Pharmaceut Corp, Dept Canc Res, West Haven, CT 06516 USA
Carter, Christopher
;
Lynch, Mark
论文数:
0
引用数:
0
h-index:
0
机构:
Bayer Pharmaceut Corp, Dept Canc Res, West Haven, CT 06516 USA
Bayer Pharmaceut Corp, Dept Canc Res, West Haven, CT 06516 USA
Lynch, Mark
;
Lowinger, Timothy
论文数:
0
引用数:
0
h-index:
0
机构:
Bayer Pharmaceut Corp, Dept Canc Res, West Haven, CT 06516 USA
Bayer Pharmaceut Corp, Dept Canc Res, West Haven, CT 06516 USA
Lowinger, Timothy
;
Dumas, Jacques
论文数:
0
引用数:
0
h-index:
0
机构:
Bayer Pharmaceut Corp, Dept Canc Res, West Haven, CT 06516 USA
Bayer Pharmaceut Corp, Dept Canc Res, West Haven, CT 06516 USA
Dumas, Jacques
;
Smith, Roger A.
论文数:
0
引用数:
0
h-index:
0
机构:
Bayer Pharmaceut Corp, Dept Canc Res, West Haven, CT 06516 USA
Bayer Pharmaceut Corp, Dept Canc Res, West Haven, CT 06516 USA
Smith, Roger A.
;
Schwartz, Brian
论文数:
0
引用数:
0
h-index:
0
机构:
Bayer Pharmaceut Corp, Dept Canc Res, West Haven, CT 06516 USA
Bayer Pharmaceut Corp, Dept Canc Res, West Haven, CT 06516 USA
Schwartz, Brian
;
Simantov, Ronit
论文数:
0
引用数:
0
h-index:
0
机构:
Bayer Pharmaceut Corp, Dept Canc Res, West Haven, CT 06516 USA
Bayer Pharmaceut Corp, Dept Canc Res, West Haven, CT 06516 USA
Simantov, Ronit
;
Kelley, Susan
论文数:
0
引用数:
0
h-index:
0
机构:
Bayer Pharmaceut Corp, Dept Canc Res, West Haven, CT 06516 USA
Bayer Pharmaceut Corp, Dept Canc Res, West Haven, CT 06516 USA
Kelley, Susan
.
NATURE REVIEWS DRUG DISCOVERY,
2006,
5
(10)
:835
-844
[14]
A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer
[J].
Yang, JC
论文数:
0
引用数:
0
h-index:
0
机构:
NCI, Surg Branch, NIH, Bethesda, MD 20892 USA
Yang, JC
;
Haworth, L
论文数:
0
引用数:
0
h-index:
0
机构:
NCI, Surg Branch, NIH, Bethesda, MD 20892 USA
Haworth, L
;
Sherry, RM
论文数:
0
引用数:
0
h-index:
0
机构:
NCI, Surg Branch, NIH, Bethesda, MD 20892 USA
Sherry, RM
;
Hwu, P
论文数:
0
引用数:
0
h-index:
0
机构:
NCI, Surg Branch, NIH, Bethesda, MD 20892 USA
Hwu, P
;
Schwartzentruber, DJ
论文数:
0
引用数:
0
h-index:
0
机构:
NCI, Surg Branch, NIH, Bethesda, MD 20892 USA
Schwartzentruber, DJ
;
Topalian, SL
论文数:
0
引用数:
0
h-index:
0
机构:
NCI, Surg Branch, NIH, Bethesda, MD 20892 USA
Topalian, SL
;
Steinberg, SM
论文数:
0
引用数:
0
h-index:
0
机构:
NCI, Surg Branch, NIH, Bethesda, MD 20892 USA
Steinberg, SM
;
Chen, HX
论文数:
0
引用数:
0
h-index:
0
机构:
NCI, Surg Branch, NIH, Bethesda, MD 20892 USA
Chen, HX
;
Rosenberg, SA
论文数:
0
引用数:
0
h-index:
0
机构:
NCI, Surg Branch, NIH, Bethesda, MD 20892 USA
Rosenberg, SA
.
NEW ENGLAND JOURNAL OF MEDICINE,
2003,
349
(05)
:427
-434
←
1
2
→