Deep brain stimulation:: response to neuronal high frequency stimulation is mediated through GABAA receptor activation in rats

被引：37

作者：

Moser, A

Gieselberg, A

Ro, B

Keller, C

Qadri, F

机构：

[1] Med Univ Lubeck, Dept Neurol, Neurochem Res Grp, D-23538 Lubeck, Germany

[2] Med Univ Lubeck, Inst Expt & Clin Pharmacol & Toxicol, D-23538 Lubeck, Germany

来源：

NEUROSCIENCE LETTERS | 2003年 / 341卷 / 01期

关键词：

high frequency stimulation; deep brain stimulation; gamma-aminobutyric acid(A) receptors; caudate nucleus; dopamine;

D O I：

10.1016/S0304-3940(03)00133-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

High frequency stimulation (HFS) of deep brain regions such as globus pallidus internus or subthalamic nucleus can reverse Parkinson's symptoms probably through activation of gamma-aminobutyric acid (GABA)ergic neurotransmission. To prove the hypothesis, rat striatal slices were stimulated electrically (130 Hz) in vitro and dopamine (DA) outflow was measured using high performance liquid chromatography. HFS induced an attenuation in basal DA release in perfusate. Veratridine-induced DA outflow was blocked by the simultaneous application of HFS. Addition of bicuculline, a GABA(A) receptor antagonist, reversed the effect of HFS on DA outflow. In addition, destruction of striatal GABAergic neurons with kainic acid also reversed the effect of HFS. In conclusion, our present data provide strong evidence that HFS does not only need presynaptic GABA(A) receptors but also intact GABAergic nerve terminals coupled to GABA(A) receptors to exert an inhibitory effect and give a rationale of HFS effectiveness in the treatment of Parkinson's disease. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：57 / 60

页数：4

共 19 条

[11] Selegiline induces dopamine release through ATP-sensitive potassium channels in the rat caudate-putamen in vitro [J].